121353-10-4Relevant articles and documents
Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment
Blanchette, Mary A.,Malamas, Michael S.,Nantz, Michael H.,Roberts, John C.,Somfai, Peter,et al.
, p. 2817 - 2825 (2007/10/02)
The synthesis of fragment AB of bryostatin 1 is described.Two aldol coupling reactions involving (i) chiral fragment A with achiral B and (ii) chiral fragment A1 with achiral A2 constitute crucial steps in which an external chiral boron reagent is used to control stereoselectivity in the creation of a new stereogenic center.This type of double asymmetric synthesis, although rarely precedented, provides a powerful means of stereocontrol over the fragment assembly.