6493-79-4

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 78-79-5 isoprene 
• 67-56-1 methanol 
• 151153-99-0 3-[(4'-methylcyclohex-3'-ene-1'-yl)carbonyl]oxazolidin-2-one 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 865-34-9 lithium methanolate 

Downstream Products

• 59498-97-4 4-Acetamido-4-methylcyclohexan-1-carbonsaeure 
• 117015-88-0 (3R,4R)-4-Bromo-3-methoxy-3-methyl-cyclohexanecarboxylic acid methyl ester 
• 115664-07-8 3-Brom-4-methoxy-4-methyl-cyclohexan-1-carbonsaeuremethylester 
• 79673-97-5 1-(1-Oxo-2-methylsulfinylethyl)-4-methyl-3-cyclohexen 
• 144686-29-3 4-hydroxy-1-(4-methyl-3-cyclohexenyl)butan-1-one 
• 29886-34-8 4-methyl-1-cyclohexanecarboxylic acid methyl ester 
• 41076-10-2 cis-4-methyl-cyclohexane-carboxylic acid-⁽¹⁾-methyl ester 
• 4342-60-3 4-methylcyclohex-3-enecarboxylic acid 
• 222555-17-1 4-methyl-1-prop-2-ynyl-cyclohex-3-enecarboxylic acid methyl ester 
• 102208-60-6 (S)-4-methyl-3-cyclohexene-1-carboxylic acid 
• 121424-36-0 (+)-(1R)-4-methyl-cyclohex-3-enecarboxylic acid 
• 37794-71-1 2-(4-methyl-3-cyclohexenyl)-1-penten-5-ol 
• 744910-18-7 propylene glycol-bis-(4-methyl-3-cyclohexenecarboxylate) 
• 805236-02-6 ethylene glycol-bis-(4-methyl-3-cyclohexenecarboxylate) 

Relevant academic research and scientific papers

CANNABINOID DERIVATIVES, PRECURSORS AND USES

The present disclosure relates to new cannabinoid derivatives and precursors and processes for their preparation. The disclosure also relates to pharmaceutical and analytical uses of the new cannabinoid derivatives.

Synthesis of gasoline and jet fuel range cycloalkanes and aromatics from poly(ethylene terephthalate) waste

For the first time, gasoline and jet fuel range C7-C8 cycloalkanes and aromatics were selectively synthesized by the alcoholysis of poly(ethylene terephthalate) (PET) waste, followed by solvent-free hydrogenation and hydrodeoxygenation (HDO). It was found that methanol is highly reactive for the alcoholysis of PET waste. In the absence of any catalyst, a high yield of dimethyl terephthalate (97.3%) was achieved under mild conditions (473 K, 3.5 h). Dimethyl terephthalate exists as a solid and can be automatically separated from methanol with a decrease in temperature. Subsequently, dimethyl terephthalate was liquefied to dimethyl cyclohexane-1,4-dicarboxylate by hydrogenation over noble metal catalysts. Among the investigated catalysts, Pt/C exhibited the highest activity. Finally, the dimethyl cyclohexane-1,4-dicarboxylate as obtained was further hydrodeoxygenated to C7-C8 cycloalkanes and aromatics that can be used as gasoline or additives to improve the densities (or volumetric heat value) and sealabilities of current bio-jet fuels. Bimetallic Ru-Cu/SiO2 was found to be a promising HDO catalyst. According to the characterization results, the excellent HDO performance of Ru-Cu/SiO2 can be explained by the formation of smaller Ru-Cu alloy particles during the catalyst preparation. In real applications, dimethyl cyclohexane-1,4-dicarboxylate can also be simultaneously hydrodeoxygenated with biomass derived oxygenates to produce jet fuel with a suitable content of cycloalkanes and aromatics.

Ni-Catalyzed chemoselective alcoholysis of: N -acyloxazolidinones

Although N-acyloxazolidinone-based (catalytic) asymmetric synthetic methodologies occupy an important position in modern organic synthesis, the catalytic cleavage of a chiral auxiliary remains underdeveloped. We report the Ni(cod)2/bipyr.-catalyzed alcoholysis of N-acyloxazolidinones to deliver esters. The reaction is broad in scope for both N-acyloxazolidinone substrates and alcohol nucleophiles, and displays good functional group tolerance and excellent chemoselectivity. A gram-scale methanolysis allowed the enantioselective synthesis of the C22-C26 segment of a close analogue of the potent immunosuppressant agent FK506.

Borenium ionic liquids as catalysts for Diels-Alder reaction: Tuneable Lewis superacids for catalytic applications

Ionic liquids based on the tricoordinate borenium cation were used for the first time as Lewis acid catalysts for a model Diels-Alder reaction. The conversion of the dienophile was successfully correlated with the Gutmann acceptor number values of the ionic liquids. Borenium ionic liquids exceeded the performance of catalysts reported in the literature.

METHODS OF SYNTHESIS OF (1R,2R,5R)-5-AMINO-2-METHYLCYCLOHEXANOL HYDROCHLORIDE AND INTERMEDIATES USEFUL THEREIN

Provided herein are methods and intermediates for making (lR,2R,5R)-5-amino-2- methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathwa

Polyelectrolyte-catalyzed Diels–Alder reactions

Imidazolium-based poly(ionic liquids) bearing bromide and bis(trifluoromethane)sulfonimide as counteranions [poly(ViEIm)Br and poly(ViEIm)NTf2] derived from reversible addition fragmentation chain transfer (RAFT) polymerization techniques are u

Silica-supported chlorometallate(iii) ionic liquids as recyclable catalysts for Diels-Alder reaction under solventless conditions

A range of Lewis acidic metal chlorides were tested as homogeneous catalysts in a model Diels-Alder reaction; AlCl3and GaCl3performed best in terms of conversion andendo : exoselectivity. Based on this outcome, the corresponding chlorometallate(iii) ionic liquids were tested as homogeneous catalysts, without a decrease in performance compared to the chlorides. Finally, these ionic liquids were heterogenised by covalent tethering of the cation onto a multimodal porous silica support; such supported chlorogallate(iii) ionic liquids are reported for the first time. Supported chlorometallate(iii) ionic liquids were used as recyclable heterogeneous catalysts for the Diels-Alder reaction under solventless conditions. High yields (99%) and highendo-selectivities (95%) were obtained after very short reaction times (5 min) at near-ambient temperature (25 °C).

Method for producing terephthalic acid

A method for producing terephthalic acid comprises the steps of: subjecting methyl acrylate to contact with aluminum chloride so as to form a complex; adding isoprene to the complex to result in a Diels-Alder reaction which is kept at a temperature no higher than 50° C. by cooling so as to obtain a cyclic adduct product; subjecting the cyclic adduct product to separation so as to obtain a cyclic para-precursor; and subjecting the cyclic para-precursor to a chemical reaction so as to obtain terephthalic acid.

Bis(phosphine)cobalt dialkyl complexes for directed catalytic alkene hydrogenation

Planar, low-spin cobalt(II) dialkyl complexes bearing bidentate phosphine ligands, (P - P)Co-(CH2SiMe3)2, are active for the hydrogenation of geminal and 1,2-disubstituted alkenes. Hydrogenation of more hindered internal and endocyclic trisubstituted alkenes was achieved through hydroxyl group activation, an approach that also enables directed hydrogenations to yield contrasteric isomers of cyclic alkanes.

Diels-alder reaction between isoprene and methyl acrylate over different zeolites: Influence of pore topology and acidity

The Diels-Alder reaction between isoprene and methyl acrylate over several zeolites was thoroughly investigated. ZSM-5 zeolites provided the highest productivity in methyl 4-methylcyclohex-3-enecarboxylate isomer, achieving 0.219mmol product per mmolHsup