121445-45-2Relevant academic research and scientific papers
Modular Access to Diverse Chemiluminescent Dioxetane-Luminophores through Convergent Synthesis
Gnaim, Samer,Gholap, Sachin Popat,Ge, Liang,Das, Sayantan,Gutkin, Sara,Green, Ori,Shelef, Omri,Hananya, Nir,Baran, Phil S.,Shabat, Doron
, (2022/04/07)
Adamantyl-dioxetane luminophores are an important class of chemiluminescent molecular probes for diagnostics and imaging. We have developed a new efficient synthetic route for preparation of adamantyl-enolether as precursors for dioxetane chemiluminescent luminophores. The synthesis is convergent, using an unusual Stille cross-coupling reaction employing a stannane-enolether, to directly afford adamantyl-enolether. In a following simple step, the dioxetane is obtained by oxidation of the enolether precursor with singlet-oxygen. The scope of this synthetic route is broad since a large number of haloaryl substrates are either commercially available or easily accessible. Such a late-stage derivatization strategy simplifies the rapid exploration of novel luminogenic molecular structures in a library format and simplifies the synthesis of known dioxetane luminophores. We expect that this new synthetic strategy will be particularly useful in the design and synthesis of yet unexplored dioxetane chemiluminescent luminophores.
Synthesis process of AMPPD
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, (2021/05/29)
The invention relates to the technical field of organic synthesis, in particular to a synthesis process of AMPPD. The synthesis process of AMPPD comprises the following steps: reacting an intermediate with molybdate in an organic solvent to form a product
Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases
Chen, Chao,Ding, Dan,Gao, Heqi,Kwok, Ryan T. K.,Ou, Hanlin,Tang, Youhong,Zheng, Donghui
, (2022/02/01)
Understanding the mechanism and progression of neutrophil-involved diseases (e.g., acute inflammation) is of great importance. However, current available analytical methods neither achieve the real-time monitoring nor provide dynamic information during th
MOLECULAR RENAL PROBES FOR DETECTING ACUTE KIDNEY INJURY
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Page/Page column 90; 91, (2020/08/22)
Disclosed herein are compounds or salts and/or solvates of formula I, II and III, where the compounds or salts and/or solvates have the following structures: (X)a-Y-(Z)b I; II; or X'-Y' III; where X, Y, Z, X', Y', a, b, R4
A novel chemiluminescent probe for hydrazine detection in water and HeLa cells
Liu, Jiang,Jiang, Jianze,Dou, Yandong,Zhang, Fangfang,Liu, Xin,Qu, Jiaojiao,Zhu, Qing
supporting information, p. 6975 - 6979 (2019/08/01)
Hydrazine is a substance harmful to humans and the environment, necessitating the development of a sensitive and specific detection method. Herein, a novel chemiluminescent probe based on Schaap's adamantylidene-dioxetane (CL-HZ) for detecting hydrazine w
A chemiluminescence sensor with signal amplification based on a self-immolative reaction for the detection of fluoride ion at low concentrations
Hisamatsu, Shugo,Suzuki, Shinichi,Kohmoto, Shigeo,Kishikawa, Keiki,Yamamoto, Yusuke,Motokawa, Ryuhei,Yaita, Tsuyoshi
, p. 3993 - 3998 (2017/06/13)
A sensory system incorporated with an amplification function was developed for the detection of trace-level fluoride ions. This sensory system comprises two steps: amplification and chemiluminescence. These steps were linked with chemical reactions and we
CHEMILUMINESCENT PROBES FOR DIAGNOSTICS AND IN VIVO IMAGING
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Paragraph 00133; 00146, (2017/08/24)
The present invention provides dioxetane-based chemiluminescence probes, more specifically ?uorophore-tethered dioxetane-based chemiluminescence probes and π* acceptor group-containing dioxetane based chemiluminescence probes, and compositions thereof. Th
Probing Force with Mechanobase-Induced Chemiluminescence
Clough, Jess M.,Balan, Abidin,Van Daal, Tom L. J.,Sijbesma, Rint P.
supporting information, p. 1445 - 1449 (2016/02/14)
Mechanophores capable of releasing N-heterocyclic carbene (NHC), a strong base, are combined with triggerable chemiluminescent substrates to give a novel system for mechanically induced chemiluminescence. The mechanophores are palladium bis-NHC complexes,
A sensitive and selective chemiluminogenic probe for palladium
Turan, Ilke Simsek,Yilmaz, Ozge,Karatas, Betul,Akkaya, Engin U.
, p. 34535 - 34540 (2015/05/04)
Palladium triggered removal of a propargyl group leads to the cleavage of the 1,2-dioxetane ring, leading to bright chemiluminescence. The reaction of the probe is highly specific for the Pd species, thus the probe described here has considerable potentia
Chemiluminescent probes for imaging H2S in living animals
Cao,Lopez,Thacker,Moon,Jiang,Morris,Bauer,Tao,Mason,Lippert
, p. 1979 - 1985 (2015/05/19)
Hydrogen sulphide (H2S) is an endogenous mediator of human health and disease, but precise measurement in living cells and animals remains a considerable challenge. We report the total chemical synthesis and characterization of three 1,2-dioxetane chemiluminescent reaction-based H2S probes, CHS-1, CHS-2, and CHS-3. Upon treatment with H2S at physiological pH, these probes display instantaneous light emission that is sustained for over an hour with high selectivity against other reactive sulphur, oxygen, and nitrogen species. Analysis of the phenol/phenolate equilibrium and atomic charges has provided a generally applicable predictive model to design improved chemiluminescent probes. The utility of these chemiluminescent reagents was demonstrated by applying CHS-3 to detect cellularly generated H2S using a multi-well plate reader and to image H2S in living mice using CCD camera technology.
