1217554-46-5

Basic information

• Product Name: 1-fluoro-4-((4-methoxyphenyl)buta-1,3-diyn-1-yl)benzene
• Synonyms: 1-fluoro-4-((4-methoxyphenyl)buta-1,3-diyn-1-yl)benzene
• CAS NO: 1217554-46-5
• Molecular Weight: 250.272
• Mol File: 1217554-46-5.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1-fluoro-4-((4-methoxyphenyl)buta-1,3-diyn-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoro-4-((4-methoxyphenyl)buta-1,3-diyn-1-yl)benzene(1217554-46-5)
• EPA Substance Registry System: 1-fluoro-4-((4-methoxyphenyl)buta-1,3-diyn-1-yl)benzene(1217554-46-5)

Safety Data

• Hazardous Substances Data: 1217554-46-5(Hazardous Substances Data)

Upstream product

• 115665-76-4 (Z)-1-(2-bromovinyl)-4-fluorobenzene 
• 768-60-5 4-methoxyphenylacetylen 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 130995-12-9 1-(4-fluorophenyl)-2-trimethylsilylacetylene 
• 95895-33-3 1-(bromoethynyl)-4-fluorobenzene 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1430102-47-8 potassium 3-(4-methoxyphenyl)propiolate 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 

Downstream Products

• 1374219-49-4 3-(4-fluorophenyl)-5-(4-methoxybenzyl)isoxazole 
• 1374219-48-3 5-(4-fluorobenzyl)-3-(4-methoxyphenyl)isoxazole 
• 1376960-39-2 2-(4-fluorophenyl)-5-(4-methoxyphenyl)furan 

Relevant articles and documents

Reduced graphene oxide supported copper oxide nanocomposites: An efficient heterogeneous and reusable catalyst for the synthesis of ynones, 1,3-diynes and 1,5-benzodiazepines in one-pot under sustainable reaction conditions

A greener and efficient method for the synthesis of ynones and 1,3-diynes using copper oxide nanoparticles (CuONPs) doped reduced graphene oxide (CuO@rGO) catalyst under palladium, ligand and solvent free conditions have been developed. The catalyst was s

Copper(II)/Palladium(II) catalysed highly selective cross-coupling of terminal alkynes in supercritical carbon dioxide

An efficient protocol for the synthesis of unsymmetrical 1,3-diynes was developed using supercritical carbon dioxide (ScCO2) as the solvent. The direct coupling of two different terminal alkynes is catalysed by a bimetallic catalyst, CuCl2·2H2O/Pd(NH3)4Cl2·H2O, in the presence of the base tetramethylethylenediamine (TMEDA) and O2. In pure ScCO2, our bimetallic catalytic system maintains high activity over a wide substrate scope to provide unsymmetrical 1,3-diynes in good to excellent yields. In the proposed reaction mechanism, the synergistic cooperation between copper(II) and palladium(II) centres is responsible for the superior selectivity of the cross-coupling.

Highly efficient synthesis of unsymmetrical 1,3-diynes from organoalane reagents and alkynyl bromides mediated by a nickel catalyst

Highly efficient and simple cross-coupling reactions of alkynylbromides with organoalane reagents for the synthesis of unsymmetrical 1,3-diynes derivatives using Ni(OAc)2 (2-5 mol%)/(o-furyl)3P (4-10 mol%) as a catalyst are reported. Excellent yields (up to 94%) were obtained for a wide range of substrates at rt or 60 °C for 2-3 h in Et2O or toluene.