121767-19-9

Basic information

• Product Name: 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene
• Synonyms: 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene
• CAS NO: 121767-19-9
• Molecular Weight: 219.359
• Mol File: 121767-19-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene(121767-19-9)
• EPA Substance Registry System: 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene(121767-19-9)

Safety Data

• Hazardous Substances Data: 121767-19-9(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 75-36-5 acetyl chloride 
• 4039-32-1 lithium hexamethyldisilazane 
• 75-77-4 chloro-trimethyl-silane 
• 120419-97-8 (E)-N-benzylidene-1,1,1-trimethylsilanamine 
• 17599-61-0 N-benzylidene-1,1,1-trimethylsilanamine 

Downstream Products

• 277303-54-5 N-benzyl(trimethylsilyl)acetamide 
• 57152-94-0 (E)-N-benzylcinnamamide 
• 66825-16-9 methyl 3-oxo-3-[(phenylmethyl)amino]propanoate 
• 121767-25-7 (2S,3R,4R)-6-Oxo-2-phenyl-piperidine-3,4-dicarboxylic acid dimethyl ester 

Relevant articles and documents

SPIROINDOLINONE DERIVATIVES

The present invention relates to spiroindolinone derivatives of the formula and their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described.

Synthesis of perhydrooxazinones from 2-aza-3-trimethylsilyloxy-1,3- butadiene. A general route to 3,3-disubstituted-β-hydroxy acids

1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene reacts with aliphatic, aromatic and cyclic ketones to give in good to excellent yields 6,6- disubstituted-1,3-perhydro-oxazin-4-ones which, in turn, have been readily converted into β-hydroxy carboxylic acids.

A REGIO- AND STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED PIPERIDONES

The new activated 2-aza-1,3-dienes 1 are readily prepared by acylation of N-trimethylsilylimines 3.They react with electrophilic olefins to yield substituted piperidones 4 and 6 with high diastereoselectivity.