1221171-69-2

Basic information

• Product Name: 2-chloro-6-(trichloroMethoxy)pyridine
• Synonyms: 2-chloro-6-(trichloroMethoxy)pyridine
• CAS NO: 1221171-69-2
• Molecular Formula: C₆H₃Cl₄NO
• Molecular Weight: 246.90612
• Mol File: 1221171-69-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-chloro-6-(trichloroMethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(trichloroMethoxy)pyridine(1221171-69-2)
• EPA Substance Registry System: 2-chloro-6-(trichloroMethoxy)pyridine(1221171-69-2)

Safety Data

• Hazardous Substances Data: 1221171-69-2(Hazardous Substances Data)

Usage

General Description

2-chloro-6-(trichloroMethoxy)pyridine is a chemical compound with the molecular formula C6H3Cl4NO. It is a chlorinated pyridine derivative that is commonly used in the manufacturing of agrochemicals and pharmaceuticals. The compound is known for its potent herbicidal and fungicidal properties, making it a valuable ingredient in pesticide formulations. Its ability to selectively target specific pests and weeds makes it a versatile and effective tool for crop protection. Due to its potential toxicity and environmental impact, the use and handling of 2-chloro-6-(trichloroMethoxy)pyridine require careful regulation and safety precautions to minimize risks to human health and the environment.

Upstream product

• 16879-02-0 6-chloro-2-pyridone 
• 463-71-8 thiophosgene 
• 16879-02-0 6-chloro-2-hydroxypyridine 

Downstream Products

• 1221171-70-5 2-chloro-6-(trifluoromethoxy)pyridine 
• 1221172-02-6 2-chloro-6-(trifluoromethoxy)-5-(trimethylsilyl)pyridine 
• 1221172-04-8 2-chloro-6-(trifluoromethoxy)nicotinic acid 
• 940895-85-2 6-(trifluoromethoxy)nicotinic acid 
• 1384878-12-9 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(R)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-11-8 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5(S)-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 
• 1384878-02-7 3-hydroxy-4-(4-isopropylbenzoyl)-1-(6-methylpyridazin-3-yl)-5-(6-(trifluoromethoxy)pyridin-3-yl)-1H-pyrrol-2(5H)-one 

Relevant articles and documents

Tri- and difluoromethoxylated N-based heterocycles ? Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

The preparation of F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid and the evaluation of their biological activity have been performed. For this purpose, a first synthetic approach allowed the preparation of a desired F3CO-containing key intermediate. To allow a facile access to the second F2HCO-containing key intermediate, the difluoromethylation of hydroxylated N-based heterocycles has been developed using difluoromethyl triflate (a liquid non-ODS reagent) under air in aqueous conditions and with very short reaction time. The broad diversity of compatible heterocycles includes a large series of substituted hydroxy-pyridines, but also ?pyrazoles, ?pyrazine, ?pyridazine, and ?quinolines. The couplings of both key intermediates with the required 4,5-dihydro-N-nitro-1H-imidazol-2-amine and [N(Z)]-N-2-thiazolidinylidene-cyanamide were successfully achieved using literature conditions. This work enables the preparation of valuable building blocks, which could lead to the discovery of new bioactive entities.

1-(6-MEMBERED AZO-HETEROCYCLIC)-2,5-DIHYDRO-1H-PYRROL-2-ONE DERIVATIVES AS ANTI-HEPATITIS C VIRUS, THE PHARMACEUTICAL COMPOSITION THEREOF AND THEIR THERAPEUTIC USE

The present invention concerns 1-(6-memberedazo-heterocyclic)-2,5-dihydro–1H–pyrrol–2-one compoundsof the following formula (I) or a salt, solvate, tautomer, isotope, enantiomer, diastereoisomer or racemic mixture thereof: the pharmaceutical composition thereof and their therapeutic use as inhibitors of Hepatitis C virus.

A general approach to (trifluoromethoxy)pyridines: First X-ray structure determinations and quantum chemistry studies

The previously unknown 2-, 3-, and 4-(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large-scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life-sciences-oriented research. In addition, the first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest-energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies. A general and efficient route to (trifluoromethoxy)pyridines is reported. Regioselective functionalization by organometallic methods afforded new and highly important building blocks for life-sciences-oriented research. The first X-ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed and supported by in silico studies.