122488-45-3

Basic information

• Product Name: [9-(3-Amino-4-chloro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine
• Synonyms: [9-(3-Amino-4-chloro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine
• CAS NO: 122488-45-3
• Molecular Weight: 370.765
• Mol File: 122488-45-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [9-(3-Amino-4-chloro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [9-(3-Amino-4-chloro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine(122488-45-3)
• EPA Substance Registry System: [9-(3-Amino-4-chloro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine(122488-45-3)

Safety Data

• Hazardous Substances Data: 122488-45-3(Hazardous Substances Data)

Upstream product

• 122488-44-2 [9-(4-Chloro-3-nitro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine 
• 55912-20-4 4-chloro-3-nitrobenzyl alcohol 
• 1998-63-6 6-chloro-2-(trifluoromethyl)-9H-purine 
• 2268-14-6 1,9-dihydro-2-(trifluoromethyl)-6H-purin-6-one 
• 122488-87-3 6-Chloro-9-(4-chloro-3-nitro-benzyl)-2-trifluoromethyl-9H-purine 
• 3360-45-0 4-chloro-3-nitro-benzylbromide 

Relevant articles and documents

Synthesis and antirhinovirus activity of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)-9H-purines

A series of 6-(dimethylamino)-2-(trifluoromethyl)-9-(substituted benzyl)purines was synthesized and tested for antirhinovirus activity. Most of the compounds were synthesized by alkylation of 6-chloro-2-(trifluoromethyl)-9H-purine with the appropriate benzyl halide followed by displacement of the chloro group with dimethylamine. Alternatively, 6-(dimethylamino)-2-(trifluoromethyl)purine was alkylated with the appropriate benzyl halide. Although several different aryl substituents provided compounds with IC50's = 0.03 μM against rhinovirus serotype 1B, no congener was significantly more active than the parent 2. Twenty-three compounds were tested against 18 other serotypes, but none exhibited a uniform profile of activity.