12266-72-7Relevant articles and documents
Coordination chemistry of the 2-pyridyidiphosphine ligands, (py)2P(CH(CH2)3CH)P(py)2 and (py)2P(CH2)2P(py)2 (py = 2-pyridyl), with platinum(II) and ruthenium(II). Ruthenium-catalyzed hydrogenation of imines
Jones, Nathan D.,MacFarlane, Kenneth S.,Smith, Martin B.,Schutte, Richard P.,Rettig, Steven J.,James, Brian R.
, p. 3956 - 3966 (1999)
The synthesis and characterization of a range of Pt(II) and Ru(II) complexes containing the new 2-pyridyldi-phosphine ligand, d(py)pcp = (py)2P(CH(CH2)3CH)P(py)2 (made as a racemate) and the previously reported d(py)pe = (py)2P(CH2)2P(py)2 are given (py = 2-pyridyl). The Pt complexes made were cis-PtX2(d(py)pcp) (X = Cl (1), I (2)), cis-PtX2(d(py)pe) (X = Cl (3), I (4)), [Pt(d(Py)pcp)2][PF6]2 (5), and [Pt(d(py)pe)2][PF6]2 (6); these all contain P,P-bonded diphosphine ligand, as evidenced by 31P NMR data and by crystallographic data in the case of 2 and 3. The X-ray structure of d(py)pe is also reported. The complexes RuX2(P,P,N-d(py)pcp)(PPh3) have cis-halogens and a P,P,N-bonding mode of the pyridyldiphosphine (which incorporates a four-membered P,N-chelate ring) with either a mer-arrangement (in 7a, X = Cl) or a fac-arrangement of the three P donor atoms (in 7b (X = Cl), 8 (X = Br), 9 (X = I)); cis-RuCl2(dppb)(P,N-PPh2(py)) (12) (dppb = Ph2P(CH2)4PPh2) is included because it has a donor set corresponding to that in 7b. Use of the purely P,P donor Ph2P(CH(CH2)3-CH)PPh2 (dppcp), made as a racemate, affords trans-RuCl2(dppcp)2 (10) and tran?-RuCl2(dppcp)(dppb) (11). Crystallographic data for 7a, 7b, and 12 are reported together with the NMR data for all the Ru complexes. Preliminary results show that the Ru complexes 7b, 8, and 9 are effective precursors for catalytic H2-hydrogenation of aldimines.
Platinum Cyclooctadiene Complexes with Activity against Gram-positive Bacteria
Frei, Angelo,Ramu, Soumya,Lowe, Gabrielle J.,Dinh, Hue,Semenec, Lucie,Elliott, Alysha G.,Zuegg, Johannes,Deckers, Anke,Jung, Nicole,Br?se, Stefan,Cain, Amy K.,Blaskovich, Mark A. T.
supporting information, p. 3165 - 3171 (2021/07/16)
Antimicrobial resistance is a looming health crisis, and it is becoming increasingly clear that organic chemistry alone is not sufficient to continue to provide the world with novel and effective antibiotics. Recently there has been an increased number of reports describing promising antimicrobial properties of metal-containing compounds. Platinum complexes are well known in the field of inorganic medicinal chemistry for their tremendous success as anticancer agents. Here we report on the promising antibacterial properties of platinum cyclooctadiene (COD) complexes. Amongst the 15 compounds studied, the simplest compounds Pt(COD)X2 (X=Cl, I, Pt1 and Pt2) showed excellent activity against a panel of Gram-positive bacteria including vancomycin and methicillin resistant Staphylococcus aureus. Additionally, the lead compounds show no toxicity against mammalian cells or haemolytic properties at the highest tested concentrations, indicating that the observed activity is specific against bacteria. Finally, these compounds showed no toxicity against Galleria mellonella at the highest measured concentrations. However, preliminary efficacy studies in the same animal model found no decrease in bacterial load upon treatment with Pt1 and Pt2. Serum exchange studies suggest that these compounds exhibit high serum binding which reduces their bioavailability in vivo, mandating alternative administration routes such as e. g. topical application.
Cytotoxicity and NMR studies of platinum complexes with cyclooctadiene ligands
Enders, Mirja,Goerling, Benjamin,Braun, Alexander B.,Seltenreich, Judith E.,Reichenbach, Linus F.,Rissanen, Kari,Nieger, Martin,Luy, Burkhard,Schepers, Ute,Braese, Stefan
supporting information, p. 4027 - 4034 (2014/10/15)
The synthesis of a series of platinum complexes containing cyclooctadiene ligands with the general structure PtMeL(R-cod) (where L = Cl, I, nC 3F7, iC3F7, nC8F 17, Me, aryl, alkynyl and R = H, Me, Et, iPr, nBu, iBu, nHex, Ph) is presented. All complexes are remarkably stable and were obtained in excellent yields. Their structure in both solution and the solid state were explored by crystal structures and multinuclear (1H, 13C, 19F, 195Pt) NMR spectroscopy. Cytotoxicity experiments with selected complexes in HeLa cells revealed higher toxicity in comparison to that of cisplatin for most of the structures.
Reaction of the carbodiphosphorane Ph3P=C=PPh3 with platinum(II) and -(0) compounds: Platinum induced activation of C-H bonds
Petz, Wolfgang,Kutschera, Christian,Neumueller, Bernhard
, p. 5038 - 5043 (2008/10/09)
The complex [(cod)PtI2] (cod = 1,5-cyclooctadiene) reacts with 3 equiv of the hexaphenyl-carbodiphosphorane Ph3P=C=PPh3 (1) in THF solution to give the novel Pt(II) complex [(η3-C 8H11)Pt(C6H4PPh2CPPh 3)] (2) along with the salt [HC(PPh3)2]I. In addition to the coordination of the ylidic carbon atom at the Pt atom, 2 contains two further Pt-C σ bonds originating from H to Pt exchange in the ortho position of one phenyl group of the carbodiphosphorane ligand and in the former cod ligand. The resulting C8H11 moiety is coordinated to the Pt atom in an η3 manner via a double bond and a σ bond and contains a further uncoordinated double bond. From a 1:1 reaction mixture in toluene/CH2Cl2 the majority of the crystals consist of the salt [HC(PPh3)2]I·2CH 2Cl2 (3) with small amounts of platinum compounds as byproducts. The Pt(0) complex [(PPh3)2Pt(CH 2=CH2)] does not react with 1 but decomposes at elevated temperatures to give the known dinuclear complex [Pt2-(PPh 3)2(μ-PPh2] (4). The complexes 2 and 4 and the salt 3 could be characterized by X-ray analyses and the usual spectroscopic methods.
