139975-98-7

Usage

Uses

Used in Agricultural Industry:
Carbamic acid, (4-hydroxy-2-naphthalenyl)-, 1,1-dimethylethyl ester is used as a pesticide and insecticide for controlling pests and insects in agricultural settings. It is effective in managing a wide range of pests that can damage crops and reduce agricultural productivity. Carbamic acid, (4-hydroxy-2-naphthalenyl)-, 1,1-dimethylethyl ester works by disrupting the nervous systems of the targeted pests, leading to their eventual death and providing protection to the crops.
Used in Residential Settings:
In residential settings, this chemical compound is used as an insecticide to control and eliminate pests that can infest homes and gardens. It is particularly useful in controlling insects that can cause damage to plants and pose health risks to humans. The application of Carbamic acid, (4-hydroxy-2-naphthalenyl)-, 1,1-dimethylethyl ester helps in maintaining a clean and safe living environment.
Safety Considerations:
It is crucial to handle Carbamic acid, (4-hydroxy-2-naphthalenyl)-, 1,1-dimethylethyl ester with care and follow proper safety protocols during its use. The chemical can be harmful if ingested or inhaled and may cause skin or eye irritation. Therefore, it is essential to use appropriate personal protective equipment (PPE) and follow the manufacturer's guidelines for safe application and disposal.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 90923-79-8 1-Hydroxy-3-naphthylamine 
• 1573-91-7 3-hydroxynaphthoic acid 
• 75-65-0 tert-butyl alcohol 
• 2764-95-6 4-methoxy-2-naphthylamine 
• 132-86-5 1,3-dihydroxynaphthalene 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 

Downstream Products

• 244154-66-3 tert-butyl (S)-1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 130008-89-8 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole 
• 161646-54-4 2-<amino>-4-(benzyloxy)-1-iodonaphthalene 
• 161646-55-5 5-(Benzyloxy)-3-(tert-butyloxycarbonyl)-1-<<(2',2',6',6'-tetramethylpiperidino)oxy>methyl>-1,2-dihydro-3H-benzindole 
• 122745-40-8 tert-Butyl(S)-5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 935764-66-2 C₂₄H₃₀ClN₃O₄ 

Relevant academic research and scientific papers

TEAD INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.

SELF-IMMOLATIVE LINKERS CONTAINING MANDELIC ACID DERIVATIVES, DRUG-LIGAND CONJUGATES FOR TARGETED THERAPIES AND USES THEREOF

The invention provides a therapeutic drug and targeting conjugate, pharmaceutical compositions containing these conjugates in pharmaceutical composition, and uses of these conjugates in anti-neoplastic and other therapeutic regimens. Also provided are novel intermediates thereof. The conjugates provide a therapeutic drug fragment or prodrug fragment bound to a targeting moiety via a linker which comprises a substrate cleavable by a protease such as Cathepsin B. The targeting moiety is a ligand which targets a cell surface molecule, such as a cell surface receptor on an anti-neoplastic cell. The ligand may function solely as a targeting moiety or may itself have a therapeutic effect. Following administration of the therapeutic drug and targeting conjugate of formula I and exposure of the conjugate to the protease specific for the substrate, the linker is cleaved and the targeting moiety is separated from the conjugate, which causes the drug fragment or prodrug fragment to convert to the drug or prodrug. The recited conjugates are useful in anti-neoplastic therapies. Also provided are methods of making the therapeutic drug and targeting conjugates and intermediates thereof, and kits comprising the therapeutic drug and targeting conjugates.

CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.

METHODS AND COMPOUNDS FOR PREPARING CC-1065 ANALOGS

A method of forming a CBI CC- 1065 analog utilizes NH2 as a starting material, where R3 is H or alkyl and R6 is H, substituted or unsubstituted lower alkyl, cyano, or alkoxy. Intermediates (I) are used and are claimed.

An Improved Synthesis of 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI): A Simplified Analogue of the CC-1065 Alkylation Subunit

A concise and improved synthesis of 11, the immediate precursor to N-BOC-CBI and related analogues of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropabenzindol-4-one alkylation subunit, is detailed based on a direct 5-exo-trig aryl radical-al