1228437-36-2

Basic information

• Product Name: 2-(4-fluorophenyl)-6-phenylpyridine
• Synonyms: 2-(4-fluorophenyl)-6-phenylpyridine
• CAS NO: 1228437-36-2
• Molecular Weight: 249.287
• Mol File: 1228437-36-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-6-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-6-phenylpyridine(1228437-36-2)
• EPA Substance Registry System: 2-(4-fluorophenyl)-6-phenylpyridine(1228437-36-2)

Safety Data

• Hazardous Substances Data: 1228437-36-2(Hazardous Substances Data)

Upstream product

• 1131-33-5 2-phenylpyridin N-oxide 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 1262526-01-1 2-(4-fluorophenyl)pyridine 1-oxide 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 29526-96-3 1-phenylcyclopropan-1-ol 
• 896885-34-0 1-(4-fluorophenyl)ethan-1-one-O-acetyl oxime 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 
• 1765-93-1 4-fluoroboronic acid 
• 898767-06-1 5-(4-fluorophenyl)-5-oxopentanenitrile 
• 98-80-6 phenylboronic acid 
• 544-13-8 Glutaronitrile 
• 296759-67-6 C₁₇H₁₃FO 
• 403-41-8 1-(4-Fluorophenyl)ethanol 

Relevant articles and documents

Palladium-Catalyzed Cascade Reactions of I-Ketonitriles with Arylboronic Acids: Synthesis of Pyridines

This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry allows 5-oxo-5-Arylpentanenitrile to react with arylboronic acids to provide unsymmetrical 2,6-diarylpyridines. This protocol paves the way for the practical and atom economical syntheses of valuable pyridines with broad functional groups in moderate to excellent yields under mild conditions.

Synthesis of Asymmetrical 2,6-Diarylpyridines from Linear α,β,γ,δ-Unsaturated Ketones by Addition of Ammonium Formate Followed by Annulation

A simple and efficient method has been established for the synthesis of asymmetrical 2,6-diarylpyridines by cyclization of α,β,γ,δ-unsaturated ketones with ammonium formate under air atmosphere. The reaction is metal-free and operationally convenient from readily available starting materials. Thirty-three examples have been presented, most of which show good yields.

C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study

An elegant pre-activation strategy, based on the formation of N-methylpyridinium iodide salts for C6-selective direct arylation of 2-phenylpyridines using Pd/Cu cooperative catalysis, has been developed. By this methodology, a wide range of unsymmetrical 2, 6-diarylpyridines were synthesized with high reactivity and regioselectivity as well as good functional group tolerance. In particular, challenging substrates bearing electron donating groups (EDGs), such as OMe, NMe2, were also successfully employed in this reaction. Deuterium incorporation studies revealed that the C?H bond acidity is improved significantly in N-methylpyridinium salts compared with their N-Oxide and N-iminopyridinium ylide counterparts, thus solving the long-standing problem associated with previous strategies for the synthesis of diaryl pyridines. Finally, the control experiments and DFT calculations supported a Pd-catalyzed and Cu-mediated mechanism in which a carbenoid copper species that is formed in-situ from N-methylpyridinium salts, participates in a Pd-catalyzed arylation followed by an iodide-promoted N-demethylation process. (Figure presented.).