122853-32-1Relevant academic research and scientific papers
Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2
Venkataramasubramanian,Sudalai, Arumugam
, p. 2099 - 2105 (2015)
A concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.
One pot synthesis of 5-(substituted aryl) methyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine using chloromethyl methyl ether
Rege, Chandana M.,Gadre,Bhalekar, Satish M.
, p. 197 - 198 (2013/09/23)
Ticlopidine and its analogues were prepared by one pot synthesis without isolating the intermediates. This sequential one pot synthesis avoided a lengthy separation process, workup and purification of the intermediate compounds and thus could save the time and resources and increased the yield.
