1229704-95-3

Basic information

• Product Name: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluorobenzoic acid
• Synonyms: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluorobenzoic acid
• CAS NO: 1229704-95-3
• Molecular Weight: 604.456
• Mol File: 1229704-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluorobenzoic acid(1229704-95-3)
• EPA Substance Registry System: 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluorobenzoic acid(1229704-95-3)

Safety Data

• Hazardous Substances Data: 1229704-95-3(Hazardous Substances Data)

Upstream product

• 1229704-94-2 4-{[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino}-2-fluoro-benzoic acid tert-butyl ester 
• 1219089-31-2 (2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carboxylic acid 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 
• 75279-53-7 2-(4-chloro-2-fluoro-phenyl)acetonitrile 
• 1219086-34-6 2-[(E)-(3,3-dimethylbutylidene)amino]acetic acid tert-butyl ester 
• 1219086-87-9 (Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile 

Relevant articles and documents

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of s