1231747-08-2

Basic information

• Product Name: L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-6-O-methyl-P-phenyl-5'-guanylyl]-, 1-methylethyl ester
• Synonyms: PSI-353661;(2S)-isopropyl-2-((((2R,3R,4R,5R)-5(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro- 3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate;(S)-isopropyl 2-(((S)-((5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
• CAS NO: 1231747-08-2
• Molecular Formula: C24H32FN6O8P
• Molecular Weight: 582.526
• Mol File: 1231747-08-2.mol
• Article Data: 6

Chemical Properties

• Density: 1.53
• CAS DataBase Reference: L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-6-O-methyl-P-phenyl-5'-guanylyl]-, 1-methylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-6-O-methyl-P-phenyl-5'-guanylyl]-, 1-methylethyl ester(1231747-08-2)
• EPA Substance Registry System: L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-6-O-methyl-P-phenyl-5'-guanylyl]-, 1-methylethyl ester(1231747-08-2)

Safety Data

• Hazardous Substances Data: 1231747-08-2(Hazardous Substances Data)

Upstream product

• 1199809-27-2 (2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol 
• 142629-80-9 phenyl methoxyalaninyl phosphorochloridate 
• 1199809-26-1 (2R,3R,4R,5R)-5-(2-amino-6-chloro-9H-purin-9-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 1256490-52-4 (S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester 
• 874638-80-9 ((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate 
• 1334513-02-8 (S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester 
• 39825-33-7 isopropyl L-alanine 
• 770-12-7 O-phenyl phosphorodichloridate 
• 1199809-24-9 (((2R,3R,4R,5R)-3-(benzoyloxy)-5-bromo-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate) 
• 1337529-56-2 (S)-2-[(S)-(2,3,4,5,6-pentafluoro-phenoxy)-phenoxy-phosphorylamino]propionic acid isopropyl ester 
• 39613-92-8 alanine isopropyl ester hydrochloride 

Relevant articles and documents

Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189

A general and efficient method for the synthesis of pronucleotide (ProTide) 5'-phosphoramidate monoesters is reported. This method consists of a highly stereoselective 5'-phosphorylation mediated by dimethylaluminum chloride to afford the desired target ProTides in excellent yields without employing 3'-protection strategies. The application of this methodology to the synthesis of a number of pharmaceutically relevant compounds currently marketed or under investigation in clinical research is demonstrated.

PHOSPHORIC ACID/PHOSPHONIC ACID DERIVATIVES AND MEDICINAL USES THEREOF

The present invention relates to phosphoric acid/phosphonic acid derivatives shown by formula (I), wherein, R1 or R2 represents the following structures: (Q1), or (Q2), or (Q3). Q1 represents ester derivatives of L-amino acid, wherein R3 is alkyl with 1-6 carbon atoms or cycloalkyl, R4 is H or alkyl with 1-6 carbon atoms; Q2 represents hydroxyl substituted benzodioxane derivatives; Q3 represents hydroxyl substituted benzodioxolane derivatives; R1 or R2 is the same or different, but at least one of them is Q2 or Q3; D represents residues of pharmacologically active molecules containing a phosphate/phosphonate group, i.e. formula (II) represents pharmacologically active molecules containing a phosphate/phosphonate group; and when R1 and R2 are different, the configuration of the P atom connected to R1 and R2 is of R or S type.

METHODS FOR TREATING HCV

This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.