2679-14-3Relevant academic research and scientific papers
New cyclic peptides from the Indonesian sponge Theonella swinhoei
Roy, Michael C.,Ohtani, Ikuko I.,Ichiba, Toshio,Tanaka, Junichi,Satari, Rachmaniar,Higa, Tatsuo
, p. 9079 - 9092 (2000)
Three new cyclic peptides, barangamides B, C, and D and a new depsipeptide, theonellapeptolide IIe as well as known theonellapeptolides Ia, Id, Ie, IId have been isolated from the sponge Theonella swinhoei collected in Baranglompo Island, Indonesia The structures of barangamides were elucidated by interpretation of NMR data and application of Marfey's method. The structure of theonellapeptolide IIe, a mixture of several conformers showing complex NMR spectra, was determined by MS analysis of a ring-opened product and by chemical reaction. Some of the theonellapeptolides showed mild immunosuppressive activity, while barangamide A was inactive. (C) 2000 Elsevier Science Ltd.
Synthesis method of 3-methylaminopropionic acid
-
Paragraph 0005; 0009, (2021/01/24)
The invention relates to a synthetic method of 3-methylaminopropionic acid. The method mainly solves the technical problems that the existing method for preparing 3-methylaminopropionic acid has manyreaction steps and is not easy for large-scale productio
Adenine receptor ligands
-
Page/Page column 15, (2010/01/29)
The invention relates to adenine receptor ligands useful for treating, alleviating and/or preventing diseases and disorders related to adenine receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviating, preventing and/or treating diseases and disorders, especially the use as antinociceptive or neuroprotective drugs.
PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT AND EXTERNAL COMPOSITION FOR SKIN
-
Page/Page column 23, (2008/06/13)
The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin -inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.
WRINKLE-IMPROVING AGENT
-
Page/Page column 20, (2008/12/06)
The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.
BETA-ALANINE N-METHYLTRANSFERASE
-
Page 32; 35-36; 42-43, (2008/06/13)
A beta -alanine NMTase was isolated from limonium latifolium . The purified enzyme catalyzes the N-methylation of beta -alanine, has an isoelectric point of about 5.15 and an apparent molecular weight of about 43 kilodaltons. A full-length cDNA encoding the NMTase was cloned by screening a L. latifolium cDNA library and was sequenced. Expression of the cDNA in transgenic, non- L. latifolium plants resulted in modulation of resistance to stress in the plants.
Reactivity and mechanism in the hydrolysis of β-sultams
Baxter, Nicholas J.,Rigoreau, Laurent J. M.,Laws, Andrew P.,Page, Michael I.
, p. 3375 - 3385 (2007/10/03)
β-Sultams show extraordinary rate enhancements of 109-and 107-fold, respectively, compared with the acid-and base-catalyzed hydrolysis of corresponding acyclic sulfonamides. They are about 103-fold more reactive than analogous β-lactams. The alkaline hydrolysis of some β-sultams shows a rate term that is second-order in hydroxide ion concentration, which is indicative of a stepwise mechanism involving a trigonal bipyramidal intermediate (TBPI). The Bronsted βlg value for the alkaline hydrolysis of N-aryl-β-sultams is -0.58 and the kinetic solvent isotope effect kH2OOH/kD2OOD is 0.60, compatible with rate-limiting formation of the TBPI. Conversely, kH2OOH/kD2OOD for N-alkyl-β-sultams is 1.55, indicative of rate-limiting breakdown of the TBPI. The acid-catalyzed hydrolysis of β-sultams is strongly retarded by electron-withdrawing groups α to the sulfonyl group, and it is suggested that the mechanism may involve unimolecular ring opening to generate a sulfonylium ion. The Bronsted βlg value for the acid-catalyzed hydrolysis of N-benzyl-β-sultams is 0.32. The general-acid-catalyzed hydrolysis of N-benzyl-β-sultam by carboxylic acids shows a Bronsted α value of 0.67 and is attributed to a specific acid-nucleophilic mechanism with the formation of a mixed-anhydride intermediate.
Catalyse intramoleculaire de l'aminolyse d'heterocycles phosphores derives des α aminoamides. I: Synthese de (thio) phosphor(N)diamides incorporant un residu de ss aminoacide
Dujols, Frederic,Jollet, Philippe,Mulliez, Michel
, p. 231 - 254 (2007/10/03)
A general scheme of intramolecular nucleophilic catalysis of aminolysis of the heterocycles B is proposed (Figure 2). The requisite heterocycle D, when built with a β aminoamide residue, allows also a repetitive β peptide synthesis, as with α aminoacids (Figure 1). In order to evaluate the feasibility of both schemes, fifteen phosphor(n)diamides (table III) incorporating one residue of β aminoacid, in form of esters 3, acids 5 (models of E, Figure 2), nitrile 11, or hydrazides 12 have been synthesized starting from P(IV) dichlorides 1 (Figure 3). Unexpectedly hydrolysis of nitriles 6 b c leads to β diacids 9 b c with the regular acids 8 b c.
A Highly Sensitive and Rapid ELISA for the Arylurea Herbicides Diuron, Monuron, and Linuron
Schneider, Peter,Goodrow, Marvin H.,Gee, Shirley J.,Hammock, Bruce D.
, p. 413 - 422 (2007/10/02)
A highly sensitive and rapid enzyme-linked immunosorbent assay (ELISA) for the detection of the arylurea herbicides monuron, diuron, and linuron is described.Diuron haptens with two different polymethylene handle location were evaluated for use as immuniz
