1241-00-5

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 17356-08-0 thiourea 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 140-89-6 potassium ethyl xanthogenate 
• 3989-50-2 4-acetamidobenzenesulfonylhydrazine 
• 1126-81-4 4-acetamidothiophenol 
• 67-64-1 acetone 
• 110-86-1 pyridine 
• 16766-09-9 (4-acetamidophenyl)disulfide 
• 64-19-7 acetic acid 
• 2987-46-4 4-thiocyanatoaniline 
• 15898-43-8 sodium 4-acetamidobenzenesulfinate 
• 722-27-0 bis(4-aminophenyl)disulfide 
• 55709-24-5 N-acetyl-sulfanilyl iodide 

Downstream Products

• 710-24-7 4-acetamidobenzenesulfinic acid 
• 35880-80-9 acetic acid-[4-(2,4-dinitro-benzenesulfonyl)-anilide] 
• 1146-45-8 4'-aminophenyl-4-aminobenzene thiolsulfonate 
• 16766-09-9 (4-acetamidophenyl)disulfide 
• 7472-15-3 4-amino benzenesulphinic acid 

Relevant academic research and scientific papers

Metal-Free Radical Annulation of Oxygen-Containing 1,7-Enynes: Configuration-Selective Synthesis of (E)-3-((Arylsulfonyl)methyl)-4-Substituted Arylidenechromene Derivatives

A novel strategy for the synthesis of (E)-3-((arylsulfonyl)methyl)-4-substituted benzylidenechromene derivatives via a metal-free radical annulation reaction of oxygen-containing 1,7-enynes with thiosulfonates has been developed. The reaction shows broad substrate scope, wide functional group tolerance, and moderate to excellent yields. Moreover, thiosulfonates were well driven to achieve the bifunctionalization reaction of oxo-1,7-enynes which derived from aliphatic alkynes. In addition, the (E)-configuration of the products was highly controlled by the structure of 1,7-enyne.

SULFENYL CHLORIDES, XIII; A NEW PROCEDURE FOR THE SYNTHESIS OF SULFONIC ACID THIOL ESTERS FROM THIOLS

Chlorination of thiols in alkali carbonate media yielded symmetrically substituted alkyl- and arylsulfonic acid thiol esters (thiosulfonates).The procedure is simple, intermediates need not be isolated.

Reactions of benzenesulfonohydrazides and benzenesulfonamides with hydrogen chloride or hydrogen bromide in acetic acid

Benzenesulfonohydrazides capable of yielding a sulfinic acid intermediate by virtue of a basic nitrogen atom in the second position of the hydrazide moiety produced thiosulfonates when treated with 1 N hydrogen chloride in acetic acid and produced disulfides when treated with 1 N hydrogen bromide in the same solvent. In two cases, a crystalline mixture of p-nitrophenyl p-nitrobenzenethiosulfonate and bis(p-nitrophenyl) disulfide was isolated from the hydrogen chloride reactions. No reaction product was obtained from either the hydrogen chloride or hydrogen bromide reaction with benzenesulfonohydrazides that were unable to form a sulfinic acid intermediate. Reduction of benzenesulfonamides to disulfides appeared to be possible only with hydrogen bromide in acetic acid. No thiosulfonate was isolated from the treatments of benzenesulfonamides with 1 N hydrogen chloride in acetic acid. p-Nitrophenyl p-nitrobenzenethiosulfonate and p-bromophenyl p-bromobenzenethiosulfonate exhibited some antimicrobial activities against Gram-positive bacteria. The latter compound also showed analgesic properties in the phenylquinone test.