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Propanoic acid,2-bromo-, (2R)- Manufacturer/High quality/Best price/In stock
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(R)-(+)-2-BromopropionicAcid
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(R)-(+)-2-Bromopropionic acid
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TIANFU-CHEM_Propanoic acid,2-bromo-, (2R)- 10009-70-8
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BLOOM TECH Advanced API/Technology support (R)-(+)-2-BROMOPROPIONIC ACID CAS 10009-70-8
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(R)-(+)-2-BROMOPROPIONIC ACID
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(R)-2-Bromopropanoic acid
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Propanoic acid, 2-bromo-, (2R)-
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10009-70-8 Usage

Purification Methods

Dissolve it in Et2O, dry (CaCl2), evaporate and distil it through a short column. Distillation through a Podbielniak column (p 11) (see S-(-)-2-chloropropionic acid below) led to decomposition. Store it in the dark under N2, preferably in sealed ampoules. Even at -10o it slowly decomposes. [Fuet et al. J Am Chem Soc 76 6054 1954, Beilstein 2 IV 761.]

Chemical Properties

clear colorless to light brown liquid
InChI:InChI=1/C3H5BrO2/c1-2(4)3(5)6/h2H,1H3,(H,5,6)/t2-/m1/s1

10009-70-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (18165)  (R)-(+)-2-Bromopropionicacid  ≥98.0% (sum of enantiomers, GC) 10009-70-8 18165-10ML 4,577.04CNY Detail
TCI America (B1756)  (R)-(+)-2-Bromopropionic Acid  >98.0%(GC) 10009-70-8 25g 2,160.00CNY Detail
TCI America (B1756)  (R)-(+)-2-Bromopropionic Acid  >98.0%(GC) 10009-70-8 5g 735.00CNY Detail

10009-70-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R)-2-bromopropanoic acid

1.2 Other means of identification

Product number -
Other names (R)-(+)-2-Bromopropionic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10009-70-8 SDS

10009-70-8Synthetic route

D-Alanine
338-69-2

D-Alanine

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With hydrogen bromide; potassium bromide; sodium nitrite at 0 - 5℃; for 1h;95%
With hydrogen bromide; potassium bromide; sodium nitrite In water at -15 - 20℃; Inert atmosphere;82%
With sulfuric acid; potassium bromide; sodium nitrite at 0 - 20℃; for 2h;41%
(S)-2-(methylsulfonyloxy)propionic acid
66423-08-3

(S)-2-(methylsulfonyloxy)propionic acid

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
Stage #1: (S)-2-(methylsulfonyloxy)propionic acid With lithium bromide In toluene at 60℃; for 1h;
Stage #2: In water; toluene at 20℃; for 0.5h;
45%
L-alanin
56-41-7

L-alanin

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With nitrosyl bromide
Stage #1: L-alanin With sulfuric acid; potassium bromide In water; toluene
Stage #2: With sodium nitrite In water; toluene at -10℃; for 18h;
n/a
Stage #1: L-alanin With sulfuric acid; potassium bromide In water
Stage #2: With sodium nitrite In water at -10℃; for 18h;
Stage #3: In water; toluene
n/a
(2R)-methyl 2-bromopropionate
20047-41-0

(2R)-methyl 2-bromopropionate

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With potassium hydroxide
2-Bromopropionic acid
598-72-1

2-Bromopropionic acid

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With Cinchonin
2-Bromopropionic acid
598-72-1

2-Bromopropionic acid

Cinchonin
118-10-5

Cinchonin

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-O-yl α-bromopropionate
167823-32-7

1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-O-yl α-bromopropionate

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran for 0.5h; Yields of byproduct given. Title compound not separated from byproducts;
2-Bromo-propionic acid (S)-4,4-dimethyl-2-oxo-1-phenyl-pyrrolidin-3-yl ester

2-Bromo-propionic acid (S)-4,4-dimethyl-2-oxo-1-phenyl-pyrrolidin-3-yl ester

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran a) -20 deg C, 2 h, b) -15 deg C, 4 h; Title compound not separated from byproducts;
L-Lactic acid
79-33-4

L-Lactic acid

phosphorus pentabromide
7789-69-7

phosphorus pentabromide

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2R)-methyl 2-bromopropionate
20047-41-0

(2R)-methyl 2-bromopropionate

aqueous KOH

aqueous KOH

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

dl-α-bromo-propionic acid

dl-α-bromo-propionic acid

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With Cinchonin
DL-<2-bromo-propionyl>-glycylglycine

DL-<2-bromo-propionyl>-glycylglycine

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With Quinine saure Hydrolyse des erhaltenen D(+)-<2-Brom-propionyl>-glycylglycins;
ester of/the/ d-lactic acid

ester of/the/ d-lactic acid

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With phosphorus pentabromide; benzene Es entstehen die Ester;
With chloroform; phosphorus pentabromide Es entstehen die Ester;
Cinchonin
118-10-5

Cinchonin

inactive α-bromo-propionic acid

inactive α-bromo-propionic acid

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

bromo-methyl-ketene
29264-45-7

bromo-methyl-ketene

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
Stage #1: bromo-methyl-ketene With n-butyllithium; diethylzinc; (S)-3-hydroxytetyrahydrofurane In hexane; toluene at -78 - 0℃; for 13h;
Stage #2: With hydrogenchloride In tetrahydrofuran at 20℃; for 48h; Title compound not separated from byproducts;
C9H21BrO2Si2

C9H21BrO2Si2

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With 2,6-di-tert-butyl-pyridine; 2.6-dimethylphenol; C32H12BF24(1-)*C44H30N2O2P(1+) In toluene at -40℃; for 24h; Inert atmosphere; Overall yield = 87 %; enantioselective reaction;
2-Bromopropionic acid
598-72-1

2-Bromopropionic acid

A

(S)-2-bromopropanoic acid
32644-15-8

(S)-2-bromopropanoic acid

B

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

Conditions
ConditionsYield
With Ν,Ν-dimethyldehydroabietylamine In chloroform-d1 at 27℃; Resolution of racemate;
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

4-aminobenzamide
2835-68-9

4-aminobenzamide

4-{[(2R)-2-bromopropanoyl]amino}benzamide

4-{[(2R)-2-bromopropanoyl]amino}benzamide

Conditions
ConditionsYield
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 20℃; for 0.5h; Inert atmosphere;100%
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 20℃; for 0.5h; Inert atmosphere;100%
styrene
292638-84-7

styrene

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

2-iodo-1-phenylethyl (2R)-2-bromopropanoate

2-iodo-1-phenylethyl (2R)-2-bromopropanoate

Conditions
ConditionsYield
With N-iodo-succinimide In dichloromethane at 20 - 22℃; for 0.25h; regioselective reaction;99%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-2-bromo-propan-1-ol
16088-61-2

(R)-2-bromo-propan-1-ol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0℃; for 3h;98%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2S,3S,6R,7S)-(-)-ethyl-3-amino-2-azido-9-(tert-butyldiphenylsiloxy)-6,7-O-isopropylidenenonanoate
1089173-91-0

(2S,3S,6R,7S)-(-)-ethyl-3-amino-2-azido-9-(tert-butyldiphenylsiloxy)-6,7-O-isopropylidenenonanoate

(2S,3S,6R,7S,2'R)-(-)-ethyl-2-azido-3-(2'-bromopropanamido)-9-(tert-butyldiphenylsilyloxy)-6,7-O-isopropylidenenonanoate
1089174-21-9

(2S,3S,6R,7S,2'R)-(-)-ethyl-2-azido-3-(2'-bromopropanamido)-9-(tert-butyldiphenylsilyloxy)-6,7-O-isopropylidenenonanoate

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;95%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2S,3S,6S,7S)-(-)-ethyl-3-amino-2-azido-9-(tert-butyldiphenylsiloxy)-6,7-O-isopropylidenenonanoate
1089174-29-7

(2S,3S,6S,7S)-(-)-ethyl-3-amino-2-azido-9-(tert-butyldiphenylsiloxy)-6,7-O-isopropylidenenonanoate

(2S,3S,6S,7S,2'R)-(-)-ethyl-2-azido-3-(2'-bromopropanamido)-9-(tert-butyldiphenylsilyloxy)-6,7-O-isopropylidenenonanoate
1089174-30-0

(2S,3S,6S,7S,2'R)-(-)-ethyl-2-azido-3-(2'-bromopropanamido)-9-(tert-butyldiphenylsilyloxy)-6,7-O-isopropylidenenonanoate

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;95%
4-n-Propylphenol
645-56-7

4-n-Propylphenol

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-2-(4-propyl-phenoxy)-propanoic acid

(R)-2-(4-propyl-phenoxy)-propanoic acid

Conditions
ConditionsYield
Stage #1: 4-n-Propylphenol; R-(+)-2-bromopropionic acid With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 5h;
Stage #2: With sodium hydroxide In tetrahydrofuran; mineral oil at 20℃; for 1h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil pH=1;
94%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2R)-methyl 2-bromopropionate
20047-41-0

(2R)-methyl 2-bromopropionate

Conditions
ConditionsYield
In diethyl ether93%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

2-methylpropan-2-thiol
75-66-1

2-methylpropan-2-thiol

(2S)-2-(tert-butylthio)propanoic acid

(2S)-2-(tert-butylthio)propanoic acid

Conditions
ConditionsYield
In ethanol92%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2''R,3''S)-(+)-tert-butyl-{N'-[3''-amino-2''-(o-nitrobenzenesulfonamido)heptanoyl]-L-alanyl}-L-valinate

(2''R,3''S)-(+)-tert-butyl-{N'-[3''-amino-2''-(o-nitrobenzenesulfonamido)heptanoyl]-L-alanyl}-L-valinate

(2''R,3''S,2'''R)-(-)-tert-butyl-{N'-[3''-(2'''-bromopropanamido)-2''-(o-nitrobenzenesulfonamido)heptanoyl]-L-alanyl}-L-valinate

(2''R,3''S,2'''R)-(-)-tert-butyl-{N'-[3''-(2'''-bromopropanamido)-2''-(o-nitrobenzenesulfonamido)heptanoyl]-L-alanyl}-L-valinate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1h; Inert atmosphere;91%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2S,3S)-N-[(1S)-2-(tert-Butyldiphenylsilyloxy)-1-methylethyl]-3-azido-4-phenyl-2-(triethylsilyloxy)butylamine
191217-13-7

(2S,3S)-N-[(1S)-2-(tert-Butyldiphenylsilyloxy)-1-methylethyl]-3-azido-4-phenyl-2-(triethylsilyloxy)butylamine

(R)-N-((2S,3S)-3-Azido-4-phenyl-2-triethylsilanyloxy-butyl)-2-bromo-N-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-propionamide
191217-14-8

(R)-N-((2S,3S)-3-Azido-4-phenyl-2-triethylsilanyloxy-butyl)-2-bromo-N-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-propionamide

Conditions
ConditionsYield
With diisopropyl-carbodiimide In dichloromethane at 0℃; for 3h;90%
With dacarbazine In dichloromethane at 0℃; for 4h; Acylation;
5-bromo-1H-indole
10075-50-0

5-bromo-1H-indole

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2S)-2-(5-bromo-1H-indol-1-yl)propanoic acid

(2S)-2-(5-bromo-1H-indol-1-yl)propanoic acid

Conditions
ConditionsYield
Stage #1: 5-bromo-1H-indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at -10℃; for 0.75h;
Stage #2: R-(+)-2-bromopropionic acid In N,N-dimethyl-formamide; mineral oil at -10 - 20℃; for 3h;
89%
p-cresol
106-44-5

p-cresol

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-2-(4-methylphenoxy)propanoic acid
14013-55-9

(R)-2-(4-methylphenoxy)propanoic acid

Conditions
ConditionsYield
Stage #1: p-cresol; R-(+)-2-bromopropionic acid With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 5h;
Stage #2: With sodium hydroxide In tetrahydrofuran; mineral oil at 20℃; for 1h;
Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil pH=1;
85%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

benzyl alcohol
100-51-6

benzyl alcohol

(R)-2-bromopropionic acid benzyl ester

(R)-2-bromopropionic acid benzyl ester

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 18h; Reflux;82%
In neat (no solvent) at 20℃; for 84h; Inert atmosphere;47%
toluene-4-sulfonic acid
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

4-aminoadamantan-1-ol
75375-89-2

4-aminoadamantan-1-ol

A

Z-(R)-2-bromo-N-(5-hydroxyadamantan-2-yl)-propionamide

Z-(R)-2-bromo-N-(5-hydroxyadamantan-2-yl)-propionamide

B

E-(R)-2-bromo-N-(5-hydroxyadamantan-2-yl)-propionamide

E-(R)-2-bromo-N-(5-hydroxyadamantan-2-yl)-propionamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;A n/a
B 81%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-2-bromopropionyl chloride
7148-74-5, 22592-73-0, 71425-59-7, 52152-04-2

(R)-2-bromopropionyl chloride

Conditions
ConditionsYield
With thionyl chloride for 6h; Heating;80%
With thionyl chloride
With thionyl chloride In diethyl ether at 0℃; for 1h;
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

2-chloro-4-methyl-benzenamine
615-65-6

2-chloro-4-methyl-benzenamine

(R)-2-bromo-N-(2-chloro-4-methylphenyl)propanamide
1429642-80-7

(R)-2-bromo-N-(2-chloro-4-methylphenyl)propanamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20 - 24℃; for 4.5h; Cooling with ice;80%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2E,4S,2'S)-4-[(2'-amino-3',3'-dimethylbutyryl)methylamino]-2,5-dimethylhex-2-enoic acid ethyl ester
187345-38-6

(2E,4S,2'S)-4-[(2'-amino-3',3'-dimethylbutyryl)methylamino]-2,5-dimethylhex-2-enoic acid ethyl ester

C20H35BrN2O4

C20H35BrN2O4

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 2h;76%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(2R,3S)-2-vinyltetrahydro-2H-pyran-3-ol
101208-75-7

(2R,3S)-2-vinyltetrahydro-2H-pyran-3-ol

C10H16O4
1243724-79-9

C10H16O4

Conditions
ConditionsYield
With sodium hydride In 1,4-dioxane69%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

bis(2-methoxyphenyl)methanamine

bis(2-methoxyphenyl)methanamine

N-(bis(2-methoxyphenyl)methyl)-2-bromopropanamide

N-(bis(2-methoxyphenyl)methyl)-2-bromopropanamide

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In tetrahydrofuran at 0 - 20℃; for 20h; Inert atmosphere;66%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-1-(4-methoxyphenyl)ethylamine
6298-96-0, 22038-86-4, 35600-82-9, 41851-59-6

(R)-1-(4-methoxyphenyl)ethylamine

(R,R)-2-bromo-N--1-(4-methoxyphenylethyl)propanamide

(R,R)-2-bromo-N--1-(4-methoxyphenylethyl)propanamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;66%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

t-butyl 4-hydroxy piperidine-1-carboxylate
109384-19-2

t-butyl 4-hydroxy piperidine-1-carboxylate

(2S)-2-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]propanoic acid
952486-63-4

(2S)-2-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]propanoic acid

Conditions
ConditionsYield
Stage #1: t-butyl 4-hydroxy piperidine-1-carboxylate With sodium hydride In 1,4-dioxane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: R-(+)-2-bromopropionic acid In 1,4-dioxane at 25℃; for 40h; Inert atmosphere;
65%
With sodium hydride In 1,4-dioxane for 22.5h;
7-hydroxy-4-methyl-chromen-2-one
90-33-5, 79566-13-5

7-hydroxy-4-methyl-chromen-2-one

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanoic acid
885126-83-0

(S)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)propanoic acid

Conditions
ConditionsYield
With potassium carbonate In acetone at 56℃; for 13h;65%
(1S)-1-(4-chlorophenylmethyl)-2-hydroxyethylamine
201864-00-8

(1S)-1-(4-chlorophenylmethyl)-2-hydroxyethylamine

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-2-bromo-N-((S)-1-(4-chlorophenyl)-3-hydroxypropan-2-yl)propanamide

(R)-2-bromo-N-((S)-1-(4-chlorophenyl)-3-hydroxypropan-2-yl)propanamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1.5h;64%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3h;64%
homoalylic alcohol
627-27-0

homoalylic alcohol

R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

C7H12O3
1243724-72-2

C7H12O3

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 20h; Reflux;53%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

S-(5'-adenosyl)-L-homocysteine
979-92-0

S-(5'-adenosyl)-L-homocysteine

(S)-carboxy-S-adenosyl-ethionine

(S)-carboxy-S-adenosyl-ethionine

Conditions
ConditionsYield
With ammonium bicarbonate at 37℃; for 18h;50%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

R,S-2,2'-(hydroxyimino)dipropionic acid
195453-23-7

R,S-2,2'-(hydroxyimino)dipropionic acid

Conditions
ConditionsYield
With sodium hydroxide; hydroxylamine hydrochloride In water at 30 - 35℃; for 40h; pH=7.2;49%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

(R)-1,1,1-trichloropent-4-en-2-ol
1421739-59-4

(R)-1,1,1-trichloropent-4-en-2-ol

(R)-1,1,1-trichloropent-4-en-2-yl (R’)-2-bromopropanoate
1421739-53-8

(R)-1,1,1-trichloropent-4-en-2-yl (R’)-2-bromopropanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1h; Steglich Esterification; Inert atmosphere;44%
R-(+)-2-bromopropionic acid
10009-70-8

R-(+)-2-bromopropionic acid

aminopropane diethyl acetal
41365-75-7

aminopropane diethyl acetal

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol
105496-31-9

N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol

C19H31N2O6PolS

C19H31N2O6PolS

Conditions
ConditionsYield
Stage #1: N-(9-fluorenylmethoxycarbonyl)-2-aminoethanol With boron trifluoride diethyl etherate In tetrahydrofuran at 20℃; for 0.5h; Wang resin;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.25h; Wang resin;
Stage #3: R-(+)-2-bromopropionic acid; aminopropane diethyl acetal; p-toluenesulfonyl chloride diastereoselective reaction; Further stages;
44%

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