1244040-64-9 Usage
Description
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate is a complex organic compound characterized by its unique molecular structure, which features a pyrrolidine ring, a tetrazinyl-benzyl group, and an oxopentanoate chain. This molecule is particularly notable for its succinimidyl ester functional group, which allows for versatile reactivity with amines, making it a valuable tool for various applications in the fields of biochemistry and materials science.
Uses
Used in Bioorthogonal Chemistry:
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate is used as a bioorthogonal reagent for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazinyl group within the molecule reacts with strained alkenes, such as transcyclooctene, norbornene, and cyclopropene, to form a stable covalent linkage. This property makes it a valuable tool for applications in biological imaging and bioconjugation, where the need for selective and non-disruptive labeling is crucial.
Used in Small Molecule and Biomolecule Modification:
In the field of chemical biology, 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate is used as a modifying agent for small molecules and biomolecules. The succinimidyl ester functional group reacts with amine groups present in target molecules, allowing for the attachment of the tetrazinyl-benzyl moiety. This modification can be employed to study the function and interactions of biomolecules or to enhance the properties of small molecules in various applications.
Used in Surface Modification:
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate is also used for surface modification, where the succinimidyl ester group can react with amine-containing surfaces, such as proteins or amine-functionalized materials. This modification can be utilized to introduce new functionalities or properties to the surface, such as improved biocompatibility, enhanced cell adhesion, or specific binding capabilities for targeted applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1244040-64-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,0,4 and 0 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1244040-64:
(9*1)+(8*2)+(7*4)+(6*4)+(5*0)+(4*4)+(3*0)+(2*6)+(1*4)=109
109 % 10 = 9
So 1244040-64-9 is a valid CAS Registry Number.
1244040-64-9Relevant articles and documents
68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers
Nichols, Brandon,Qin, Zhengtao,Yang, Jun,Vera, David R.,Devaraj, Neal K.
, p. 5215 - 5217 (2014)
We have developed a 68Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo. the Partner Organisations 2014.
Interfacial tetrazine click chemistry mediated assembly of multifunctional colloidosomes
Pahwa, Meenakshi,Jain, Priyanka,Das Saha, Nilanjana,Narayana, Chandrabhas,Agasti, Sarit S.
, p. 9534 - 9537 (2021/09/28)
We demonstrate that tetrazine ligation chemistry can be employed to cross-link and assemble gold nanoparticles at the water-oil interface to create plasmonic colloidosomes. These biocompatible colloidosomes exhibit size tunabilityviacontrollable ligation kinetics and display high encapsulation efficiency, size-selective permeability, and surface-enhanced Raman scattering (SERS)-based sensing modality.
