82419-32-7

Basic information

• Product Name: 2-Acetonyloxy-3,4-difluoro nitrobenzene
• Synonyms: TIMTEC-BB SBB009909;2-ACETONYLOXY-3,4-DIFLUORO NITROBENZENE;[(2,3-DIFLUORO-6-NITRO) PHENOXY] ACETONE;1-(2,3-DIFLUORO-6-NITROPHENOXY)-2-PROPANONE;2-Acetonyloxo-3,4-difluoronitrobenzene;1-(2,3-Difluoro-6-nitrophenoxy;1-Acetone-oxo-3,4-difluoro-nitrobenzene;1-(2,3-Difluoro-6-nitrophenoxy)acetone
• CAS NO: 82419-32-7
• Molecular Formula: C₉H₇F₂NO₄
• Molecular Weight: 231.15
• Mol File: 82419-32-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 40-45 °C
• Boiling Point: 335.4 °C at 760 mmHg
• Flash Point: 156.6 °C
• Appearance: Yellow crystalline powder
• Density: 1.41 g/cm³
• Vapor Pressure: 0.00012mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Acetonyloxy-3,4-difluoro nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetonyloxy-3,4-difluoro nitrobenzene(82419-32-7)
• EPA Substance Registry System: 2-Acetonyloxy-3,4-difluoro nitrobenzene(82419-32-7)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-25
• Safety Statements: 37/39-26-45
• Hazardous Substances Data: 82419-32-7(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

InChI:InChI=1/C9H7F2NO4/c1-5(13)4-16-9-7(12(14)15)3-2-6(10)8(9)11/h2-3H,4H2,1H3

Upstream product

• 771-69-7 2,3,4-trifluoronitrobenzene 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 78-95-5 chloroacetone 

Downstream Products

• 124506-30-5 2,3-Difluoro-6-nitro-{[(S)-2-hydroxypropyl]oxy}benzene 
• 117321-75-2 2-(2,2-ethylenedioxypropyloxy)-3,4-difluoronitrobenzene 
• 186750-51-6 (S)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 124409-98-9 (R)-1-(6-amino-2,3-difluorophenoxy)propan-2-ol 
• 145757-92-2 (R)-1-(2,3-difluoro-6-nitrophenoxy)propan-2-yl acetate 
• 124409-94-5 2,3-difluoro-6-nitro{[(R)-2-hydroxypropyl]oxy}benzene 
• 117321-76-3 2-(2,2-ethylenedioxypropyloxy)-3,4-difluoroaniline 
• 86794-25-4 9-(4-Benzyl-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 86794-24-3 8-Fluoro-3-methyl-6-oxo-9-(4-phenyl-piperazin-1-yl)-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 124255-93-2 8-Fluoro-3-methyl-6-oxo-9-(4-propyl-piperazin-1-yl)-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 124338-73-4 9-(4-Ethyl-piperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 
• 82419-52-1 N-Demethylofloxacin 
• 82419-34-9 ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate 
• 131683-67-5 9-(3-Amino-pyrrolidin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid 

Relevant articles and documents

Enantioselective Biocatalytic Reduction of 2 H-1,4-Benzoxazines Using Imine Reductases

A biocatalytic reduction of 2H-1,4-benzoxazines using imine reductases is reported. This process enables a smooth and enantioselective synthesis of the resulting cyclic amines under mild conditions in aqueous media by means of a catalytic amount of the cofactor NADPH as hydride source as well as glucose as the reducing agent used in stoichiometric amounts for in situ cofactor recycling. Several substrates were studied, and the 3,4-dihydro-2H-1,4-benzoxazines were obtained with up to 99% ee. In addition, the efficiency of this reduction process based on imine reductases as catalysts has been demonstrated for one 2H-1,4-benzoxazine on an elevated laboratory scale running at a substrate loading of 10 g L-1 in the presence of a tailor-made whole-cell catalyst.

Chemoenzymatic Asymmetric Synthesis of 1,4-Benzoxazine Derivatives: Application in the Synthesis of a Levofloxacin Precursor

A versatile and general route has been developed for the asymmetric synthesis of a wide family of 3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazines bearing different pattern substitutions in the aromatic ring. Whereas hydrolases were not suitable for resoluti

Benzoxazine derivatives

Pyrido[1,2,3-de][1,4]benzoxazine derivatives are described having the formula (I) STR1 wherein X is a halogen atom, R is a hydrogen atom or an alkyl group of 1 to 6 carbon atoms and Z represents mono-substituted, di-substituted or cyclic-substituted amino group which may contain a hetero atom and may have a substituent such as hydroxyl, alkyl having 1 to 6 carbon atoms, amino, hydroxyalkyl having 1 to 6 carbon atoms or mono- or di-alkylamino having 1 to 6 carbon atoms in each alkyl moiety and the pharmaceutically acceptable salt thereof, having antibacterial activity.