1246949-34-7Relevant articles and documents
Synthesis of the antiproliferative agent hippuristanol and its analogues via Suárez cyclizations and Hg(II)-catalyzed spiroketalizations
Ravindar, Kontham,Reddy, Maddi Sridhar,Lindqvist, Lisa,Pelletier, Jerry,Deslongchamps, Pierre
, p. 1269 - 1284 (2011/04/26)
A full account of the synthesis of hippuristanol and its analogues is described. Hecogenin acetate was identified as a suitable and economical starting material for this work, and substrate-controlled stereoselection was obtained throughout the construction of the key spiroketal unit. Suárez cyclization was first used, but Hg(II)-catalyzed spiroketalization of the 3-alkyne-1,7-diol motif was finally identified as the most convenient strategy.(Figure Presented)