1246973-69-2

Upstream product

• 99-90-1 para-bromoacetophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 67-68-5 dimethyl sulfoxide 
• 299456-72-7 1-(4-bromophenyl)ethanone O-acetyl oxime 
• 121-69-7 N,N-dimethyl-aniline 
• 59862-55-4 p-bromoacetophenone oxime 
• 150-30-1 Phenylalanine 
• 56-40-6 glycine 
• 63-91-2 L-phenylalanine 

Relevant academic research and scientific papers

Decarboxylative cyclization of amino acids towards the Regioselective synthesis of 2,4-diarylpyridines via relay Fe(III)/In(III)-catalysis

A competent relay Fe(III)-/In(III)-catalyzed decarboxylative cyclization of amino acids has been devised towards the exclusive preparation of 2,4-diarylpyridines. The efficacy of the developed conditions drives the reaction towards selective formation of 2,4-diarylpyridines over other pyridine derivatives. The described protocol showed good functional group tolerance with moderate to good yields of products.

Pd-Catalyzed Decarboxylation and Dual C(sp3)-H Functionalization Protocols for the Synthesis of 2,4-Diarylpyridines

The Pd-catalyzed decarboxylation and dual C(sp3)-H bond functionalization approaches have been described for the preparation of symmetrical and unsymmetrical 2,4-diarylpyridines. The developed transformations were realized using nonactivated aromatic ketones and amino acids as C-N sources. The efficacy of the catalyst and reagent combination drives the transformation toward the formation of desired products with high yields and selectivity. The described reaction conditions have seduced the self-reaction of phenylalanine via [2 + 2 + 2] cycloaddition and minimized the formation of 3,5-phenylpyridine as a side product, whereas using glycine as a C-N source, the corresponding 2,6-diarylpyridines were formed as minor products.

Iron-Catalyzed Cyclization of Ketoxime Carboxylates and Tertiary Anilines for the Synthesis of Pyridines

A novel and efficient iron-catalyzed cyclization of ketoxime carboxylates and N,N-dialkylanilines for the modular synthesis of diverse pyridines was developed. The reaction was initiated by Fe-catalyzed N-O bond cleavage of ketoxime carboxylates in the presence of tertiary anilines. The methylene carbon on N,N-dialkylanilines functioned as a source of one-carbon synthon in the reaction. The reaction used readily available starting materials, tolerated various functional groups, and afforded 2,4-disubstituted and 2,4,6-trisubstituted pyridines in good to high yields under mild conditions.

Ammonium iodide-promoted cyclization of ketones with DMSO and ammonium acetate for synthesis of substituted pyridines

A simple and efficient method has been developed for the synthesis of symmetrical and unsymmetrical pyridines via NH4I-promoted cyclization of ketones with DMSO and NH4OAc. It was found that methyl ketones always gave selective forma

Synthesis of 2,4-diarylsubstituted-pyridines through a Ru-catalyzed four component reaction

A ruthenium-catalyzed one-pot synthesis of 2,4-diarylsubstituted pyridines from acetophenones, ammonium acetate and DMF under an oxygen atmosphere is described. The carbon atom situated at C6 of the pyridine ring comes from the methyl group of DMF and the nitrogen atom comes from ammonium acetate.

Simple selective synthesis of 2,4- and 2,6-diarylpyridines through metal-free cyclocondensation of aromatic ketones with ammonium acetate

A simple and selective one-pot synthesis of 2,4- and 2,6-diarylpyridines through the cyclocondensation reaction of aromatic ketones with ammonium acetate has been developed. The procedure is metal-free, convenient, and efficient, and the substrates are re