1247725-89-8Relevant articles and documents
Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl) methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists
Bai, Renren,Wei, Zhen,Liu, Jie,Xie, Weijia,Yao, Hequan,Wu, Xiaoming,Jiang, Jieyun,Wang, Qiujuan,Xu, Jinyi
, p. 4661 - 4667 (2012/09/07)
A series of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives (Ia-Il) were synthesized and biologically evaluated. It was found that Ig, the most active compound, antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50 = 8.5, ETA IC50 = 8.9 nM), and was more potent than losartan in RHRs with no significant effect on heart rate. The preliminary structure-activity relationships were also discussed in the present paper.