1247822-08-7

Basic information

• Product Name: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one
• Synonyms: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one
• CAS NO: 1247822-08-7
• Molecular Weight: 341.152
• Mol File: 1247822-08-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one(1247822-08-7)
• EPA Substance Registry System: 3-(4-bromophenyl)-2,2-difluoro-3-hydroxy-1-phenylpropan-1-one(1247822-08-7)

Safety Data

• Hazardous Substances Data: 1247822-08-7(Hazardous Substances Data)

Upstream product

• 114701-62-1 ethyl 2,2-difluoro-3-oxo-3-phenylpropanoate 
• 1885-87-6 benzaldehyde-N,N-pentamethylene hydrazone 
• 1122-91-4 4-bromo-benzaldehyde 
• 86340-78-5 2,2-difluoro-1-phenyl-1-trimethylsiloxyethene 
• 1610-04-4 α-bromo-α,α-difluoro-acetophenone 
• 62305-65-1 p-bromo-N-(p-bromobenzylidene)aniline 
• 92207-60-8 ethyl 2,2-difluoro-3-hydroxy-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Relevant articles and documents

Copper-Catalyzed Reaction of Trifluoromethylketones with Aldehydes via a Copper Difluoroenolate

A copper-catalyzed reaction of easily accessible α,α,α-trifluoromethylketones with various aldehydes affords difluoro-methylene compounds in the presence of diboron and NaOtBu. The key process of the reaction is the formation of a copper difluoroenolate by 1,2-addition of a borylcopper intermediate to α,α,α-trifluoromethylketones and subsequent β-fluoride elimination. Mechanistic studies including the isolation and characterization of a possible anionic copper alkoxide intermediate are also described.

Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction

A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid has been developed under mild conditions. This method provides a new route for the direct one-pot synthesis of difluorinated aldols in moderate to good yields from simple substrates.

Metal-mediated Reformatsky reaction of bromodifluoromethyl ketone and aldehyde using water as solvent

Water is demonstrated as a suitable solvent for an efficient and environmentally friendly method for the synthesis of α,α- difluorinated β-hydroxy carbonyl compounds through the Reformatsky reaction of bromodifluoromethyl ketones with aldehydes in the pre