1248593-30-7Relevant articles and documents
N-acetonitrile dibenzenesulfonimide derivative as well as preparation method and application thereof
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Paragraph 0053-0066, (2021/07/08)
The invention belongs to the technical field of organic synthesis chemistry, and particularly provides an N-acetonitrile dibenzenesulfonimide derivative as well as a preparation method and application thereof. The structure of the N-acetonitrile dibenzenesulfonimide derivative is shown as a formula (1), wherein R or R1 is selected from one of hydrogen, halogen, C1-C6 linear chain or branched chain alkyl, C1-C6 linear chain alkoxy, nitryl, an ester group, trifluoromethyl, trifluoromethoxy, acetyl, a fused ring group and a heterocyclic ring group. The synthesis method comprises the following steps of: taking a hydroxyl alkenyl azide compound and N-fluorobenzenesulfonamide as raw materials, and synthesizing the compound shown in the formula (1) under the combined action of an additive and a catalyst. According to the method, the N-acetonitrile dibenzenesulfonimide derivative can be rapidly and effectively synthesized, the reaction condition is mild, and toxic and side products are avoided.
A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: Design, synthesis, and in vitro activity
Alexiou, Polyxeni,Demopoulos, Vassilis J.
supporting information; experimental part, p. 7756 - 7766 (2011/02/22)
We have previously reported the successful replacement of a carboxylic acid functionality with that of a difluorophenolic group on the known aldose reductase inhibitors (ARIs) of 2-(phenylsulfonamido)acetic acid chemotype. In the present work, based on bi
