67571-10-2Relevant articles and documents
Electron density guided fragment-based lead discovery of ketohexokinase inhibitors
Gibbs, Alan C.,Abad, Marta C.,Zhang, Xuqing,Tounge, Brett A.,Lewandowski, Francis A.,Struble, Geoffrey T.,Sun, Weimei,Sui, Zhihua,Kuo, Lawrence C.
, p. 7979 - 7991 (2010)
A fragment-based drug design paradigm has been successfully applied in the discovery of lead series of ketohexokinase inhibitors. The paradigm consists of three iterations of design, synthesis, and X-ray crystallographic screening to progress low molecula
