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1254473-68-1

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1254473-68-1 Usage

Description

(R)-1-(3,5-dichloropyridin-4-yl)ethanol is a chiral alcohol with the molecular formula C7H7Cl2NO. It features a pyridine ring to which two chlorine atoms are attached, giving it unique chemical properties. (R)-1-(3,5-dichloropyridin-4-yl)ethanol is utilized in the fields of organic synthesis and medicinal chemistry, primarily as a building block for the creation of pharmaceuticals and agrochemicals. Its potential applications extend to anti-inflammatory and anti-cancer treatments, as well as antifungal and antibacterial properties, although further research is necessary to fully elucidate its therapeutic potential and biological activities.

Uses

Used in Pharmaceutical Industry:
(R)-1-(3,5-dichloropyridin-4-yl)ethanol is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features, which can be incorporated into drug molecules to enhance their therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, (R)-1-(3,5-dichloropyridin-4-yl)ethanol is utilized as a building block for the development of new agrochemicals, potentially improving the efficacy of pesticides and other agricultural products.
Used in Medicinal Chemistry Research:
(R)-1-(3,5-dichloropyridin-4-yl)ethanol is employed as a research compound for exploring its potential as an anti-inflammatory agent, given its capacity to modulate biological pathways associated with inflammation.
Used in Cancer Research:
(R)-1-(3,5-dichloropyridin-4-yl)ethanol is used as a subject of study in cancer research, examining its potential to act as an anti-cancer agent, which could be instrumental in developing novel therapeutics for various types of cancer.
Used in Antimicrobial Research:
(R)-1-(3,5-dichloropyridin-4-yl)ethanol is also being investigated for its potential antifungal and antibacterial properties, which could lead to its use in the development of new antimicrobial agents to combat drug-resistant infections.

Check Digit Verification of cas no

The CAS Registry Mumber 1254473-68-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,4,7 and 3 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1254473-68:
(9*1)+(8*2)+(7*5)+(6*4)+(5*4)+(4*7)+(3*3)+(2*6)+(1*8)=161
161 % 10 = 1
So 1254473-68-1 is a valid CAS Registry Number.

1254473-68-1Downstream Products

1254473-68-1Relevant articles and documents

VINYL COMPOUNDS AS FGFR AND VEGFR INHIBITORS

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Paragraph 0208; 0209, (2018/06/23)

FGFR and VEGFR inhibitors are provided, and compounds represented by formula (1) or formula (II) as FGFR and VEGFR inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.

Discovery of 3-(5′-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation

Yan, Wei,Wang, Xinyi,Dai, Yang,Zhao, Bin,Yang, Xinying,Fan, Jun,Gao, Yinglei,Meng, Fanwang,Wang, Yuming,Luo, Cheng,Ai, Jing,Geng, Meiyu,Duan, Wenhu

, p. 6690 - 6708 (2016/08/06)

Fibroblast growth factor receptor (FGFR) represents an attractive oncology target for cancer therapy in view of its critical role in promoting cancer formation and progression, as well as causing resistance to approved therapies. In this article, we describe the identification of the potent pan-FGFR inhibitor (R)-21c (FGFR1-4 IC50 values of 0.9, 2.0, 2.0, and 6.1 nM, respectively). Compound (R)-21c exhibited excellent in vitro inhibitory activity against a panel of FGFR-amplified cell lines. Western blot analysis demonstrated that (R)-21c suppressed FGF/FGFR and downstream signaling pathways at nanomolar concentrations. Moreover, (R)-21c provided nearly complete inhibition of tumor growth (96.9% TGI) in NCI-H1581 (FGFR1-amplified) xenograft mice model at the dose of 10 mg/kg/qd via oral administration.

PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2

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Page/Page column 53, (2011/12/02)

A compound of formula la or formula lb, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4-7-heterocycloalkyl; - CONR4R5; -NHCO

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