42716-73-4 Usage
General Description
Bromo-cyclohexyl-acetic acid ethyl ester is a chemical compound with the molecular formula C10H15BrO2. It is an ester derivative of cyclohexylacetic acid, and it contains a bromine atom. BROMO-CYCLOHEXYL-ACETIC ACID ETHYL ESTER is classified as a carboxylic acid ester, and it is commonly used as an intermediate in the synthesis of organic compounds. Bromo-cyclohexyl-acetic acid ethyl ester has applications in the pharmaceutical and agrochemical industries, where it is utilized in the production of various drugs and pesticides. It is also used as a chemical building block in the manufacture of specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 42716-73-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,7,1 and 6 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 42716-73:
(7*4)+(6*2)+(5*7)+(4*1)+(3*6)+(2*7)+(1*3)=114
114 % 10 = 4
So 42716-73-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H17BrO2/c1-2-13-10(12)9(11)8-6-4-3-5-7-8/h8-9H,2-7H2,1H3
42716-73-4Relevant articles and documents
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Richter, Hans G.F.,Benson,Bleicher,Blum,Chaput,Clemann,Feng,Gardes,Grether,Hartman,Kuhn,Martin,Plancher,Rudolph,Schuler,Taylor
, p. 1134 - 1140 (2011/04/16)
Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6- difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice.
