125873-80-5Relevant academic research and scientific papers
Highly stereoselective synthesis of mupirocin H
Sengupta, Sandip,Kim, Hak Joong,Cho, Kyung Seon,Song, Woon Young,Sim, Taebo
, p. 1182 - 1189 (2017/02/18)
A highly diastereoselective and efficient convergent synthesis of mupirocin H starting from (+)-(R)-Roche ester was achieved. Grubbs cross metathesis was employed as the key step in the pathway to generate an important E-olefin intermediate. Other process
Catalytic diastereoselective reduction of α,β-epoxy and α,β-aziridinyl ynones
Druais, Valerie,Meyer, Christophe,Cossy, Janine
supporting information; scheme or table, p. 516 - 519 (2012/03/26)
The Noyori transfer hydrogenation of α,β-epoxy and α,β-aziridinyl ynones leads to the corresponding α,β-epoxy or α,β-aziridinyl propargylic alcohols with high reagent-controlled diastereoselectivity.
Total synthesis of scytophycin C. 1. Stereoselective syntheses of the C(1)-C(18) segment and the C(19)-C(31) segment
Nakamura, Ryoichi,Tanino, Keiji,Miyashita, Masaaki
, p. 3579 - 3582 (2007/10/03)
[Equation presented] Stereoselective total synthesis of scytophycin C, a marine 22-membered macrolide displaying potent activity against a variety of human carcinoma cell lines, has been reported in which the polypropionate structure bearing contiguous as
Synthetic Studies on Polypropionate Antibiotics Based on the Stereospecific Methylation of γ,δ-Epoxy Acrylates by Trimethylaluminum. A Highly Stereoselective Construction of the Eight Contiguous Chiral Centers of Ansa-chains of Rifamycins
Miyashita, Masaaki,Yoshihara, Kousei,Kawamine, Katsumi,Hoshino, Masahide,Irie, Hiroshi
, p. 6285 - 6288 (2007/10/02)
A highly stereoselective construction of the eight contiguous chiral centers of ansa-chains of rifamycins has been accomplished by the iterative use of the stereospecific methylation of γ,δ-epoxy acrylates by trimethylaluminum which was recently developed
Synthesis, conformation, and immunosuppressive activity of cyclosporines that contain ε-oxygen (4R)-4-[(E)-butenyl]-4,N-dimethyl-L-threonine analogues in the 1-position
Sun,Guillaume,Dunlap,Rich
, p. 1443 - 1452 (2007/10/02)
A series of CsA analogues that contain novel ε-oxygen isosteres of (4R)-4-[(E)-butenyl]-4,N-dimethyl-L-threonine (MeBmt) in the 1-position were synthesized. The key steps for the syntheses of enantiomerically pure ε-oxygen MeBmt analogues 4-7 were based o
NEW ALLYLSTANNANES FOR THE CONNECTIVE CONSTRUCTION OF MONOPROTECTED VICINAL DIOLS
Keck, Gary E.,Abbott, Duain E.,Wiley, Michael R.
, p. 139 - 142 (2007/10/02)
The preparation of allylstannanes 1a-c, all of which bear an oxygen substituent at the allylic terminus, is desribed.These reagents react with alpha- and beta-alkoxyaldehydes in the presence of MgBr2 as Lewis acid to give SE' products with diastereofacial selectivity consistent with "chelation control"; a syn disposition of substituents about the newly formed bond is highly favored in all cases.
