1259017-53-2

Basic information

• Product Name: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate
• Synonyms: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate
• CAS NO: 1259017-53-2
• Molecular Weight: 629.176
• Mol File: 1259017-53-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate(1259017-53-2)
• EPA Substance Registry System: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl morpholine-4-carbodithioate(1259017-53-2)

Safety Data

• Hazardous Substances Data: 1259017-53-2(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 75-15-0 carbon disulfide 
• 1259017-73-6 N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine 
• 692059-41-9 6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline 
• 574738-93-5 6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol 
• 6702-50-7 3-hydroxy-4-methoxybenzoate 
• 645-08-9 Isovanillic acid 
• 380844-24-6 methyl 5-(3-chloropropoxy)-4-methoxy-2-nitrobenzoate 
• 380844-26-8 methyl 5-(3-chloropropoxy)-2-amino-4-methoxybenzoate 
• 380844-22-4 methyl 3-(3-chloropropoxy)-4-methoxybenzoate 

Relevant articles and documents

Novel EGFR inhibitors prepared by combination of dithiocarbamic acid esters and 4-anilinoquinazolines

On the basis of combination strategy, a novel series of EGFR inhibitors were designed and synthesized by combination of dithiocarbamic acid esters and 4-anilinoquinazolines. The effect of the synthesized compounds on cell proliferation was evaluated by MTT assay in three human cancer cell lines: MDA-MB-468, SK-BR-3 and HCT-116. Two compounds (11d and 11f) were found more potent against all three cell lines and five compounds (11a, 11d-11g) were found more potent against both MDA-MB-468 and SK-BR-3 than Lapatinib. SAR studies revealed that the substituents on C6 and C7 positions of quinazoline, the amine component of dithiocarbamate moiety and the linker greatly affected the activity. This work provides a promising new strategy for the preparation of potent tyrosine kinase inhibitors.