1259396-68-3

Upstream product

• 100-39-0 benzyl bromide 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 1259396-54-7 (S)-2-ethylaminobutanoic acid benzyl ester 
• 80226-63-7 (S)-2-amino-butyric acid benzyl ester 
• 95656-92-1 benzyl (S)-2-((tert-butoxycarbonyl)amino)butanoate 

Relevant academic research and scientific papers

NOVEL THIOPHENECARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

The object of the present invention is to provide a compound having a glucokinase-activating effect. A pharmaceutical composition comprising a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein X means a nitrogen atom or CR6, wherein R6 means a hydrogen atom or a halogen atom; R1 means a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 alkylthio group; R2 means a hydrogen atom or a fluorine atom; R3 means a hydrogen atom or a C1-C6 alkyl group; and one of R4 and R5 means a hydrogen atom or a C1-C6 alkyl group, and the other means a C1-C6 alkylenecarboxylic acid, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, or CONH2.