1260146-93-7

Upstream product

• 7138-34-3 p-chloromandelic acid 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 104-88-1 4-chlorobenzaldehyde 
• 32174-34-8 methyl 4-chloromandelate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 66985-46-4 (+/-)-2-(4-chlorophenyl)-2-(trimethylsiloxy)-acetonitrile 

Downstream Products

• 1260146-56-2 1-hydroxy-1-(4-chlorophenyl)-3-phenylpropanone 
• 854676-79-2 1-hydroxy-1-(4-chlorophenyl)-3-phenylpropanone 
• 1260146-94-8 C₁₆H₂₆ClNO₃Si 

Relevant academic research and scientific papers

Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

The first successful example of the direct synthesis of Weinreb amides using catalytic hydroxy-directed dehydrative amidation of carboxylic acids using the diboronic acid anhydride catalyst is described. The methodology is applicable to the concise syntheses of eight α-hydroxyketone natural products, namely, sattabacin, 4-hydroxy sattabacin, kurasoins A and B, soraphinols A and B, and circumcins B and C.

Enantioselective aerobic oxidation of α-hydroxy-ketones catalyzed by oxidovanadium(V) methoxides bearing chiral, N-salicylidene- tert -butylglycinates

Chiral oxidovanadium(V) methoxides prepared from 3,5-disubstituted-N- salicylidene-l-tert-butylglycines and vanadyl sulfate in air-saturated MeOH serve as highly enantioselective catalysts for asymmetric aerobic oxidations and kinetic resolution of alkyl, aryl, and heteroaryl α-hydroxy-ketones with differed α-substituents at ambient temperature in toluene or TBME (tert-butyl methyl ether). The best scenarios involve the use of complexes which bear the tridendate templates derived from 3,5-diphenyl- or 3-o-biphenyl-5-nitro-salicyaldehyde. The kinetic resolution selectivities of the aerobic oxidation process are in the range of 12 to >1000 based on the selectivity factors (krel).