126087-69-2

Upstream product

• 126087-62-5 (E)-ethyl 3-phenyl-2-(phenylsulfonyl)acrylate 
• 623-73-4 diazoacetic acid ethyl ester 
• 768-49-0 (2-methyl-1-propenyl)-benzene 
• 126113-01-7 (2S,3R)-2-Benzenesulfonyl-4-methyl-4-nitro-3-phenyl-pentanoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 126087-64-7 1-Benzenesulfonyl-2,2-dimethyl-3-phenyl-cyclopropanecarboxylic acid ethyl ester 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 64-17-5 ethanol 
• 4192-77-2 ethyl cinnamate 
• 13133-96-5 4-hydroxy-4-methyl-3-phenylpentanoic acid γ-lactone 
• 5281-20-9 acetone hydrazone 

Downstream Products

• 157240-02-3 methyl (1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylate 
• 50672-13-4 (±)-trans-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 51974-64-2 (±)-trans-(2,2-dimethyl-3-phenylcyclopropyl)methanol 
• 4489-17-2 (+/-)-2,2-dimethyl-3t-phenyl-cyclopropane-r-carbonyl chloride 
• 494846-26-3 (+)-trans-(1R,3R)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 494846-57-0 (-)-trans-(1S,3S)-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid 
• 1557243-20-5 (1R,3R)-N-[5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2,2-dimethyl-3-phenylcyclopropanecarboxamide 
• 1610023-35-2 C₁₂H₁₃ClO 
• 78003-28-8 trans-2,2-Dimethyl-3-(4-brom-phenyl)-cyclopropan-carbonsaeure-⁽¹⁾ 

Relevant academic research and scientific papers

Cycloaddition Reactions of Alkene Radical Cations using Iron(III)-Phenanthroline Complex

Single electron oxidation of electron-rich alkenes using the iron(III)-phenanthroline complex produced electrophilic alkene radical cations, which promoted efficient radical cation [2+1] cycloaddition reactions with diazo compounds. Subsequent chain propagation afforded tri- and tetra-substituted cyclopropanes. This methodology was also expanded to [3+2] cycloaddition reactions with vinyl diazoesters, validating this sustainable, first-row transition metal iron system for the single electron redox reactions. (Figure presented.).

ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds of Formula (IVA), or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof: Formula (IVA), wherein "RIa", "RIb", "RIc", "RId", "RIe", are defined herein above, which compounds are believed suitable for use in positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR) receptors, for example, those found in the cerebral cortex and the hippocampus. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Alzheimer's disease (AD), schizophrenia, and Parkinson's disease (PD), or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.

α7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I

The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of α7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases.

A general stereoselective method for the synthesis of cyclopropanecarboxylates. A new version of the homologous Horner-Wadsworth- Emmons reaction

The synthesis of α-, β- and γ-substituted α-phosphono-γ-lactones was accomplished using different ring closure and ring homologation strategies. It was found that the lactones could be selectively transformed into the corresponding ethyl cyclopropanecarboxylates by treatment with sodium ethoxide in boiling THF. The reported reaction provides an attractive alternative to the classical homologous Horner-Wadsworth-Emmons approach to the construction of cyclopropanes with electron-withdrawing functionalities. This journal is The Royal Society of Chemistry.

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1

A novel series of arylcyclopropanecarboxyl guanidines was synthesized and evaluated for activity against the sodium hydrogen exchanger isoform-1 (NHE-1). In biological assays conducted in an AP1 cell line expressing the human NHE-1 isoform, the starting cyclopropane 3a (IC50 = 3.5 μM) shows inhibitory activity comparable to cariporide (IC50 = 3.4 μM). Structure-activity relationships are used to optimize the affinity of various acyl guanidines for NHE-1 by screening the effect of substituents at both aryl and cyclopropyl rings. It is demonstrated that introduction of appropriate hydrophobic groups at the phenyl ring and a gem-dimethyl group at the cyclopropane ring enhances the NHE-1 inhibitory activity by up to 3 orders of magnitude (compound 7f, IC50 = 0.003 μM). In addition, the gem-dimethyl series of analogues seem to display improved oral bioavailability and longer plasma half-life in rats. Furthermore, the lead benzodihydrofuranyl analogue 1 (BMS-284640) shows over 380-fold increased NHE-1 inhibitory activity as well as improved selectivity for NHE-1 over NHE-2 compared to cariporide.

A FACILE SYNTHESIS OF ETHYL 3-ARYL-2,2-DIMETHYLCYCLOPROPANECARBOXYLATES, INTERMEDIATES FOR PYRETHROID ACARICIDES

A facile three step synthesis of 3-aryl-2,2-dimethylcyclopropanecarboxylates, intermediates for pyrethroid acaricides, involving formation of arylidene phenylsulfonylacetate, MIRC reaction of the cyclopropane intermediate with sodium amalgam in fair overa