1262680-53-4Relevant academic research and scientific papers
Synthesis of Naamidine A and Selective Access to N2-Acyl-2-aminoimidazole Analogues
Gibbons, Joseph B.,Salvant, Justin M.,Vaden, Rachel M.,Kwon, Ki-Hyeok,Welm, Bryan E.,Looper, Ryan E.
, p. 10076 - 10085 (2015)
A short and scalable synthesis of naamidine A, a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation, has been achieved. A key achievement in this synthesis was the development of a
COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES
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Paragraph 0185, (2015/11/10)
The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.
Concise and diversity-oriented route toward polysubstituted 2-aminoimidazole alkaloids and their analogues
Ermolat'Ev, Denis S.,Bariwal, Jitender B.,Steenackers, Hans P. L.,De Keersmaecker, Sigrid C. J.,Van Der Eycken, Erik V.
supporting information; experimental part, p. 9465 - 9468 (2011/02/28)
Alkaloids of the naamine family were synthesized from diverse propargylamines in just two steps (see scheme: R1=Me, R 2=substituted benzyl, R3=Ar). Thus, the addition to a propargylamine of a carbodiimide generated in situ
