1263-79-2

Usage

Uses

Used in Traditional Chinese Medicine:
L-Tetrandrine is used as a traditional remedy for various health conditions, leveraging its anti-inflammatory, anti-cancer, and anti-fibrosis properties to address a range of ailments.
Used in Cardiovascular Treatment:
L-Tetrandrine is used as a calcium channel blocker in the treatment of cardiovascular diseases, potentially offering a new avenue for managing conditions related to heart health.
Used in Anticancer Therapy:
L-Tetrandrine is used as an anticancer agent, targeting the inhibition of tumor growth and progression, and may be further explored for its synergistic effects with conventional chemotherapeutic drugs.
Used in Antiviral Development:
L-Tetrandrine is used as a potential antiviral agent, with research indicating its ability to combat viral infections, positioning it as a candidate for new treatments in infectious disease management.
Used in Immunomodulatory Applications:
L-Tetrandrine is used as an immunomodulatory substance, suggesting its potential to regulate immune responses, which could be beneficial in treating immune-related disorders.

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 110360-02-6 (-)-2,2'-bisnorphaeanthine 
• 518-34-3 Tetrandrin 
• 477-57-6 pheanthine 
• 5487-33-2 O-benzylhomoisovanillic acid 
• 23428-79-7 2-(3-Benzyloxy-4-methoxy-phenyl)-N-[2-(3-bromo-4,5-dimethoxy-phenyl)-ethyl]-acetamide 
• 38849-51-3 1-(3-benzyloxy-4-methoxy-benzyl)-8-bromo-6,7-dimethoxy-3,4-dihydro-isoquinoline 
• 23495-75-2 1-(3-benzyloxy-4-methoxy-benzyl)-8-bromo-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline 
• 23495-76-3 1-(3-benzyloxy-4-methoxy-benzyl)-8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 121-33-5 vanillin 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 63909-38-6 3-methoxy-4-benzyloxy-ω-nitrostyrolene 
• 22231-61-4 2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine 

Downstream Products

• 477-57-6 tetrandrine 
• 5096-70-8 (-)-(R)-(N)-methylcoclaurine 
• 58169-28-1 secophaeanthine 
• 115439-17-3 pycmanilline 
• 5701-00-8 (R)-O-methylarmepavine 
• 3423-05-0 (R)-7-methoxy-1-(4-methoxy-benzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol 
• 3423-07-2 (S)-N-methylcoclaurine 
• 436-77-1 demethyltetrandrine 
• 479-37-8 (+)-obamegine 
• 2107-55-3 (R)-6-ethoxy-7-methoxy-1-(4-methoxy-benzyl)-2-methyl-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

Full-synthetic method of racemic tetrandrine

The invention discloses a full-synthetic method of racemic tetrandrine, and belongs to the technical field of drug synthesis. The full-synthetic method of the racemic tetrandrine comprises the steps that a synthetic route adopts a convergence synthesis method, a 5-bromovanillin, namely a compound 1 and 3-hydroxy-4-methoxyphenylacetic acid, namely a compound 5 are taken as starting materials to obtain a compound 4 and a compound 6 respectively, then the compound 4 and the compound 6 are taken as raw materials to synthesize a compound 11, a compound 19 is synthesized from the compound 11, and finally, the compound 11 reacts with the compound 19. The full-synthetic method of the racemic tetrandrine has the advantages that the synthetic efficiency is higher, the yield is higher, and the cost is lower; the reaction conditions are milder, the operation is simple and convenient, the industrial value is higher, and a reference is provided for the full-synthetic method of optical voidness tetrandrine.

ALKALOIDS OF DEHAASIA TRIANDRA

Separation of the basic fraction from Dehaasia triandra afforded two new bisbenzylisoquinoline alkaloids, dehatridine and dehatrine, along with six known alkaloids, isocorydine, corytuberine, atheroline, nantenine, obaberine and a quaternary aporphine alkaloid, xanthoplanine (5). - Keywords: Dehaasia triandra; Lauraceae; Iau-Guoo-Nan; bisbenzylisoquinoline alkaloids; dehatridine; dehatrine.

Alcaloides bisbenzylisoquinoleiques de Albertisia cf. A. papuana

Four new bisbenzylisoquinoline alkaloids were obtained from Albertisia cf.A. papuana Becc. (Menispermaceae).These are (-)-2,2'-bisnorphaeanthine (5), (+)-pangkoramine (7), (+)-pangkorimine (9), and (+)-2'-norcocsuline (14).They are accompanied by the known (+)-daphnoline (2), which is the main alkaloid, and by seven known dimers with one, two, or three ether bridges