126440-96-8Relevant articles and documents
A three-component, general and practical route for diastereoselective synthesis of aza-spirocyclic pyrazolonesviaa decarboxylative annulation process
Awasthi, Annapurna,Yadav, Pushpendra,Tiwari, Dharmendra Kumar
, p. 2374 - 2383 (2021)
An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available α-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This
Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones: Via dual α′,α′-C(sp3)-H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones
Zhang, Jiayong,Miao, Zhiwei
, p. 9461 - 9471 (2019/01/03)
A bisphosphine-catalyzed sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones has been developed. Under the catalysis of DPPB [1,4-bis(diphenylphosphino)butane], the reaction proceeded smoothly to give spiro-[cyclopentanone] pyrazolone derivatives in moderate to good yields with good diastereoselectivities via sequential dual α′,α′-C(sp3)-H bifunctionalization annulation. This strategy provides a novel route toward the synthesis of spiro-[cyclopentanone] pyrazolones containing three contiguous stereocenters which possess potential pharmaceutical activities.
α,β-Unsaturated Nitriles in Heterocyclic Synthesis: The Reaction of β-(2-Furanyl)- and β-(2-Thienyl)acrylonitrile with Active Methylene Reagents
Girgis, Nabih Saddik,Elgemeie, Galal Eldin Hamza,Nawar, Galal Abdel Moein,Elnagdi, Mohamed Hilmy
, p. 1468 - 1475 (2007/10/02)
The reactions of β-(2-furanyl)- and β-(2-thienyl)acrylonitrile with a variety of active methylene reagents are described.The investigations make several new pyran and pyranodiazole derivatives accessible.
