126495-44-1

Basic information

• Product Name: 1-(2-bromophenyl)-2-methyl-propan-2-ol
• Synonyms: 1-(2-bromophenyl)-2-methyl-propan-2-ol
• CAS NO: 126495-44-1
• Molecular Weight: 229.117
• Mol File: 126495-44-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(2-bromophenyl)-2-methyl-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromophenyl)-2-methyl-propan-2-ol(126495-44-1)
• EPA Substance Registry System: 1-(2-bromophenyl)-2-methyl-propan-2-ol(126495-44-1)

Safety Data

• Hazardous Substances Data: 126495-44-1(Hazardous Substances Data)

Usage

Description

1-(2-bromophenyl)-2-methyl-propan-2-ol, also known as alpha-bromo-2-methylpropylbenzyl alcohol, is an organic compound characterized by its chemical formula C10H13BrO. This colorless liquid features a benzene ring with a bromine atom at the 2-position and a methyl group on the 2-carbon of the propan-2-ol moiety. It is utilized as an intermediate in the synthesis of pharmaceuticals and other organic compounds, as well as serving as a reagent in organic chemistry reactions. Due to its hazardous nature, it is crucial to handle this compound with care to avoid skin and eye irritation.

Uses

Used in Pharmaceutical Synthesis:
1-(2-bromophenyl)-2-methyl-propan-2-ol is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows for the creation of a wide range of medicinal compounds, contributing to the development of novel treatments for different health conditions.
Used in Organic Chemistry Reactions:
In the field of organic chemistry, 1-(2-bromophenyl)-2-methyl-propan-2-ol serves as a valuable reagent. Its presence in reactions can facilitate the formation of specific products or enhance the efficiency of certain processes, making it an essential component in the synthesis of various organic compounds.

Upstream product

• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 
• 74-88-4 methyl iodide 
• 18698-97-0 ortho-bromophenylacetic acid 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 75-16-1 methylmagnesium bromide 
• 21906-31-0 1-(2-bromophenyl)propane-2-one 

Downstream Products

• 1431526-04-3 9-[2-(2-hydroxy-2-methylpropyl)phenyl]-10-methylacridinium ion 
• 6337-33-3 2,2-dimethyl-2,3-dihydro-1-benzofuran 

Relevant articles and documents

An efficient route to: N -alkylated 3,4-dihydroisoquinolinones with substituents at the 3-position

A facile synthetic procedure for the production of N-alkylated 3,4-dihydroisoquinolinone derivatives is described. The desired products were obtained by N-alkylation of 3,3′-dimethyl-3,4-dihydroisoquinoline derivatives followed by oxidation of the resulting iminium salts. Reaction conditions for both steps were very mild and the desired cyclization products could be obtained in good yield. This strategy allows the generation of N-substituted 3,4-dihydroisoquinolinone derivatives with substituents at the 3-position.

1-(3-QUINOLYL)-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AS FUNGICIDES FOR COMBATING SPECIFIC PHYTOPATHOGENS

1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.