126866-24-8

Basic information

• Product Name: 1-Propanone, 1-(4-chlorophenyl)-2-phenyl-
• CAS NO: 126866-24-8
• Molecular Formula: C15H13ClO
• Molecular Weight: 244.721
• Mol File: 126866-24-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(4-chlorophenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(4-chlorophenyl)-2-phenyl-(126866-24-8)
• EPA Substance Registry System: 1-Propanone, 1-(4-chlorophenyl)-2-phenyl-(126866-24-8)

Safety Data

• Hazardous Substances Data: 126866-24-8(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 790-41-0 4-chlorobenzoic anhydride 
• 106-39-8 bromochlorobenzene 
• 25145-43-1 2-phenylpropionyl chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 10108-64-2 cadmium(II) chloride 
• 144930-50-7 mesityl(phenyl)iodonium triflouromethanesulfonate 
• 122-01-0 4-chloro-benzoyl chloride 
• 104-88-1 4-chlorobenzaldehyde 
• 67-56-1 methanol 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 3262-89-3 triphenylboroxine 
• 20461-80-7 1-(4-chlorophenyl)-2-diazo-propan-1-one 
• 304477-64-3 1-chloro-4-(1-phenylprop-1-enyl)benzene 

Downstream Products

• 47648-24-8 (2-{4-[(E)-1-(4-Chloro-phenyl)-2-phenyl-propenyl]-phenoxy}-ethyl)-diethyl-amine 

Relevant articles and documents

Enantioselective α-Arylation of Ketones via a Novel Cu(I)-Bis(phosphine) Dioxide Catalytic System

A novel catalytic system based on copper(I) and chiral bis(phosphine) dioxides is described. This allows the arylation of silyl enol ethers to access enolizable α-arylated ketones in good yields and enantiomeric excess up to 95%. Noncyclic ketones are amenable substrates with this method, which complements other approaches based on palladium catalysis. Optimization of the ligand structure is accomplished via rational design driven by correlation analysis. Preliminary mechanistic hypotheses are also evaluated in order to identify the role of chiral bis(phosphine) dioxides.

C -Methylation of Alcohols, Ketones, and Indoles with Methanol Using Heterogeneous Platinum Catalysts

A versatile, selective, and recyclable heterogeneous catalytic method for the methylation of C-H bonds in alcohols, ketones, and indoles with methanol under oxidant-free conditions using a Pt-loaded carbon (Pt/C) catalyst in the presence of NaOH is reported. This catalytic system is effective for various methylation reactions: (1) the β-methylation of primary alcohols, including aryl, aliphatic, and heterocyclic alcohols, (2) the α-methylation of ketones, and (3) the selective C3-methylation of indoles. The reactions are driven by a borrowing-hydrogen mechanism. The reaction begins with the dehydrogenation of the alcohol(s) to afford aldehydes, which subsequently undergo a condensation reaction with the nucleophile (aldehyde, ketone, or indole), followed by hydrogenation of the condensation product by Pt-H species to yield the desired product. In all of the methylation reactions explored in this study, the Pt/C catalyst exhibits a significantly higher turnover number than other previously reported homogeneous catalytic systems. Moreover, it is demonstrated that the high catalytic activity of Pt can be rationalized in terms of the adsorption energy of hydrogen on the metal surface, as revealed by density functional theory calculations on different metal surfaces.

Iron-Catalyzed Acylation of Polyfunctionalized Aryl- and Benzylzinc Halides with Acid Chlorides

FeCl2 (5 mol %) catalyzes a smooth and convenient acylation of functionalized arylzinc halides at 50 °C (2-4 h) and benzylic zinc chlorides at 25 °C (0.5-4 h) with a variety of acid chlorides leading to polyfunctionalized diaryl and aryl heteroaryl ketones.