127221-54-9

Upstream product

• 127221-57-2 N-benzyl-trans-(2R,5R)-bis(benzyloxymethyl)-pyrrolidine 
• 24211-51-6 (2S,5S)-hexane-1,2,5,6-tetrol 
• 93713-36-1 1-Benzyl-[(2R,5R)-2,5-bis(hydroxymethyl)]pyrrolidine 
• 127221-55-0 1,6-di-O-benzyl-3,4-dideoxy-D-threo-hexitol 
• 127221-56-1 1,6-di-O-benzyl-2,5-di-O-tosyl-3,4-dideoxy-D-threo-hexitol 
• 146547-21-9 C₂₀H₂₆O₈S₂ 
• 146547-11-7 (2S,5S)-1,6-bis[(tert-butyldiphenylsilyl)oxy]hexane-2,5-diol 
• 146547-12-8 1,6-di-O-(tert-butyldiphenyl)silyl-2,5-di-O-isopropylidene-3,4-dideoxy-D-threo-hexitol 
• 146547-15-1 1,6-di-O-(t-butyl-diphenyl)-silyl-2,5-di-O-tosyl-3,4-dideoxy-D-threo-hexitol 
• 3268-36-8 1,2:5,6-di-O-isopropylidene-3,4-O-thioxocarbonyl-D-mannitol 
• 31843-48-8 trans-3,4-Didehydro-3,4-dideoxy-1,2:5,6-di-O-isopropyliden-D-threo-hexitol 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 127305-27-5 1,2-bis<(4S)-2,2-dimethyl-1,3-dioxolan-4-yl>ethane 
• 146547-14-0 1,6-di-O-benzyl-2,5-di-O-isopropylidene-3,4-dideoxy-D-threo-hexitol 

Downstream Products

• 156875-61-5 N,N'-(diselenodi-2,1-phenylenemethylene)bis<(2R,5R)-bis(benzyloxymethyl)pyrrolidine> 

Relevant academic research and scientific papers

A straightforward synthesis of enantiomerically pure trans-2,5-bis(alkyloxymethyl) pyrrolidines by 1,3-dipolar cycloaddition reactions of azomethine ylides

A new efficient method for the stereoselective preparation of trans-2,5-bis(alkyloxymethyl)pyrrolidines (7) using easily available starting materials is described. The main step of this synthesis is the stereoselective formation of the pyrrolidine ring by

Synthesis of Enantiomerically Pure (2R,5R) Disubstituted Pyrrolidines from D-Mannitol

Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form.Some comments and studies regarding pyrrolidine ring closure (key step) are also reported.

ASYMMETRIC SYNTHESIS OF TRANS-(2R,5R)-BIS(BENZYLOXYMETHYL)PYRROLIDINE

Trans-(2R,5R)-bis(benzyloxymethyl)-pyrrolidine (1) was prepared from 1,2:5,6-diisopropylidene mannitol.Key transformations included the selective protection of primary hydroxy groups and stereocontrolled cyclization.