1272654-63-3

Basic information

• Product Name: N-methyl-N-(2-fluorophenyl)formamide
• Synonyms: N-methyl-N-(2-fluorophenyl)formamide
• CAS NO: 1272654-63-3
• Molecular Weight: 153.156
• Mol File: 1272654-63-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(2-fluorophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(2-fluorophenyl)formamide(1272654-63-3)
• EPA Substance Registry System: N-methyl-N-(2-fluorophenyl)formamide(1272654-63-3)

Safety Data

• Hazardous Substances Data: 1272654-63-3(Hazardous Substances Data)

Upstream product

• 824-48-6 N-(2-fluorophenyl)formamide 
• 616-38-6 carbonic acid dimethyl ester 
• 348-54-9 2-Fluoroaniline 
• 124-38-9 carbon dioxide 
• 1978-38-7 2-fluoro-N-methylaniline 
• 667-27-6 Ethyl bromodifluoroacetate 
• 109-94-4 formic acid ethyl ester 
• 67-66-3 chloroform 

Downstream Products

• 1978-38-7 2-fluoro-N-methylaniline 

Relevant articles and documents

Mild, simple, and efficient method for N-formylation of secondary amines via Reimer-Tiemann reaction

A rapid and easy route for the N-formylation of secondary amines using chloroform and sodium ethoxide via dichlorocarbene by the Riemer-Tiemann reaction with excellent yield is reported.

Zinc Powder Catalysed Formylation and Urealation of Amines Using CO2 as a C1 Building Block?

Transformation of CO2 into valuable organic compounds catalysed by cheap and biocompatible metal catalysts is one of important topics of current organic synthesis and catalysis. Herein, we report the zinc powder catalysed formylation and urealation of amines with CO2 and (EtO)3SiH under solvent free condition. Using 2 molpercent zinc powder as the catalyst, a series of secondary amines, both the aromatic ones and the aliphatic ones, can be formylated into formamides. When primary aromatic amines were used as the substrates, the reactions produce urea derivatives. The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed. The recovery and reusability of zinc powder were investigated, showing the zinc powder can be reused in the formylation reaction without loss of catalytic activity. The analysis on the reactants/products mixture after filtering out the zinc powder showed the zinc concentration in the mixture is low to 1 ppm. The pathways for the formylation and urealation of amines with this catalytic system were also investigated, and related to the different substrates.

The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles

A mild and efficient method for the synthesis of cyanoformamides from N,N-disubstituted aminomalononitriles with CsF as the promoter has been developed. This method features a wide substrate scope and high reaction efficiency, and will facilitate corresponding cyanoformamide-based biological studies and synthetic methodology development.