1273-74-1Relevant articles and documents
The Unusual Redox Properties of Fluoroferrocenes Revealed through a Comprehensive Study of the Haloferrocenes
Inkpen, Michael S.,Du, Shuoren,Hildebrand, Mariana,White, Andrew J. P.,Harrison, Nicholas M.,Albrecht, Tim,Long, Nicholas J.
, p. 5461 - 5469 (2015)
We report the synthesis and full characterization of the entire haloferrocene (FcX) and 1,1′-dihaloferrocene (fcX2) series (X = I, Br, Cl, F; Fc = ferrocenyl, fc = ferrocene-1,1′-diyl). Finalization of this simple, yet intriguing set of compoun
Evidence for “Halogen-Dance” and Ring-Exchange Reactions in Chloro-methylthio-ferrocenes
Blockhaus, Tobias,Bernhartzeder, Stefanie,Kempinger, Werner,Klein-He?ling, Christian,Weigand, Stefan,Sünkel, Karlheinz
, p. 6576 - 6587 (2020)
The pentachloroferrocenes [C5Cl5]Fe[C5H4X] (X = H, Br, SMe) react with LiTMP and MeSSMe to form mixtures of compounds, that contain besides the expected products of deprotonation also one or more complexes with a [C5Cl4(SMe)] ligand. This latter observation makes the otherwise rarely observed occurrence of “halogen dance reactions” in chloroaromatics very probable. 1,2,3-Trichloroferrocene yields with BuLi and MeSSMe products of both halogen-metal-exchange and of deprotonation. Additionally, in all examined systems, the observation of some highly-substituted complexes with eight or more substituents hints to the involvement of cyclopentadienyl exchange reactions, which has also rarely been observed under such mild conditions. The molecular structures of [C5Cl4(SMe)]Fe[C5H3BrX] (X = SMe or SOMe), [C5Cl4(SMe)]Fe[C5H2Cl(SMe)2], [C5Cl2(SMe)3]2Fe, and [C5HCl3(SMe)]2Fe have been determined by X-ray diffraction.
Regorafenib analogues and their ferrocenic counterparts: Synthesis and biological evaluation
Wilde, Myron,Arzur, Danielle,Baratte, Blandine,Lefebvre, Dorian,Robert, Thomas,Roisnel, Thierry,Le Jossic-Corcos, Catherine,Bach, Stéphane,Corcos, Laurent,Erb, William
supporting information, p. 19723 - 19733 (2020/12/04)
Approved by the FDA in 2012, regorafenib is one of the last chance treatments for colorectal cancer. While various analogues have already been prepared, ferrocenic derivatives have never been evaluated. In this study, we prepared various ferrocene-containing derivatives of regorafenib and recorded their biological activity in kinase and cellular assays. This led to the identification of a squaramide derivative which shows a good cellular activity and three ferrocene analogues with promising activity in both kinase and cellular assays. This journal is
BASELESS NUCLEOTIDE ANALOGUES AND USES THEREOF
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Paragraph 0112; 0113, (2014/05/07)
A method of detecting a target nucleic acid.
