127418-31-9Relevant articles and documents
Deciphering the mechanism behind efficient enantioselective ethylation with thiazolidine-based amino alcohols
Tavares, Nélia C. T.,Cacho, Vanessa R. G.,Costa, Dora C. S.,Nunes, Sandra C. C.,Pais, Alberto A. C. C.,Murtinho, Dina,Silva Serra, M. Elisa
, (2022/01/08)
Taking advantage of the opposite chirality of two privileged starting materials, l-cysteine and d-penicillamine, a wide range of thiazolidine-based amino alcohols was synthesized. l-Cysteine derivatives were more efficient chiral inductors than the d-peni
2,2′-Bipyridine-α,α′-trifluoromethyl-diol ligand: Synthesis and application in the asymmetric Et2Zn alkylation of aldehydes
Lauzon, Samuel,Ollevier, Thierry
supporting information, p. 11025 - 11028 (2021/11/03)
A chiral 2,2′-bipyridine ligand (1) bearing α,α′-trifluoromethyl-alcohols at 6,6′-positions was designed in five steps affording either the R,R or S,S enantiomer with excellent stereoselectivities, i.e. 97% de, >99% ee and >99.5% de, >99.5% ee, respectively. The key step for reaching high levels of stereoselectivity was demonstrated to be the resolution of the α-CF3-alcohol using (S)-ibuprofen as the resolving agent. An initial application for the 2,2′-bipyridine-α,α′-CF3-diol ligand was highlighted in the ZnII-catalyzed asymmetric ethylation reaction of aromatic, heteroaromatic, and aliphatic aldehydes. Synergistic electron deficiency and steric hindrance properties of the newly developed ligand afforded the corresponding alcohols in good to excellent yields (up to 99%) and enantioselectivities (up to 95% ee). As observed from single crystal diffraction analysis, the complexation of the 2,2′-bipyridine-α,α′-CF3-diol ligand generates an unusual hexacoordinated ZnII.
Method for preparing 2-acyl furan
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Paragraph 0021, (2019/12/25)
The invention relates to a method for preparing 2-acyl furan. The method is characterized by comprising the following steps: (1) controlling the temperature to -10-40 DEG C, and adding 70-98% of a water phase or 10-90% of a mixed liquid of the water phase and an organic phase, 0.0001-2.0% of an osmium compound and 0.001-5.0% of an amine compound into a reaction container so as to obtain a reactionliquid; (2) feeding the reaction liquid into a sealed reactor, and performing gas exchange to provide an aerobic environment for reactions; (3) adding 1-(2-furyl)-1-alkyl methanol into the sealed reactor, and controlling the pressure to 0-20MPa and the temperature to 0-200 DEG C for 1-74 hours; and (4) after the reaction is stopped, performing cooling to the room temperature, performing pressurerelease to the barometric pressure, adding sodium hydrogen sulfate and acetic acid, performing extraction, and performing organic phase vacuum distillation refining, so as to obtain a 2-acyl furan product. The method has the advantages that technical and economical defects of a conventional synthesis route can be avoided, process procedures can be reduced, consumption and emission can be reduced,the energy consumption and the cost can be lowered, and the method is applicable to capacity increase industrial production.
