127459-91-0

Upstream product

• 92114-96-0 mercury fulminate 
• 108-88-3 toluene 
• 54043-60-6 1,3,5-tris(o-tolyl)-hexahydro-s-triazine 
• 38362-89-9 1-methyl-2-(2-nitroethyl)benzene 
• 95-46-5 2-methylphenyl bromide 
• 14683-79-5 (E)-2-methylbenzaldehyde oxime 
• 95-53-4 o-toluidine 
• 529-20-4 2-methylphenyl aldehyde 
• 5470-11-1 hydroxylamine hydrochloride 
• 53724-30-4 o-Methyl-dithiobenzoesaeure 

Downstream Products

• 529-20-4 2-methylphenyl aldehyde 
• 26995-43-7 2-methyl-benzaldehyde (E)-O-(1,1-dioxo-1H-1λ⁶-benzo[d]isothiazol-3-yl)-oxime 
• 527-85-5 o-Methylbenzamid 
• 1383823-83-3 4-((8-azabicyclo[3.2.1]octan-3-yloxy)methyl)-5-cyclopropyl-3-(o-tolyl)isoxazole 
• 1383823-81-1 tert-butyl 3-((5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1383823-79-7 4-(bromomethyl)-5-cyclopropyl-3-(o-tolyl)isoxazole 
• 1383823-77-5 (5-cyclopropyl-3-(o-tolyl)isoxazol-4-yl)methanol 
• 161864-07-9 E-(R)-1-(2-((((2-methylphenyl)methylene)amino)oxy)ethyl)-3-piperidinecarboxylic acid ethyl ester hydrochloride 
• 160655-87-8 2[3-(2-Methylphenyl)-isoxazol-5-yl]-phenylglyoxylic acid methyl ester-O-methyloxime 
• 89-93-0 ortho-methylbenzylamine 

Relevant academic research and scientific papers

Visible-light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes

A visible light mediated stereospecific C(sp2)-H difluoroalkylation of (Z)-aldoximes to (E)-difluoroalkylated ketoximes has been described. In this reaction, (hetero)-aromatic and aliphatic difluoroalkylated ketoximes could be obtained with the retention of the configuration of the starting aldoximes. A preliminary mechanism study showed that a difluoromethyl radicalviaan SET pathway was involved.

CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines

This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials. Readily accessed ally

One-pot two-step sequential transformation: Highly efficient construction of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers

A practical variety of o-2,3,5,6-tetrafluorobenzonitrile substituted oximes ethers bearing broad functional groups were synthesized in moderate to good yields. The key highlight of this disclosure involving a one-pot two-step tandem procedure in aqueous media: the in situ formation of aryl aldehydes or ketones oximes followed by the SNAr reaction with pentafluorobenzonitrile via the high selective CF bond cleavage.

Palladium-catalyzed nitromethylation of aryl halides: An orthogonal formylation equivalent

An efficient cross-coupling reaction of aryl halides and nitromethane was developed with the use of parallel microscale experimentation. The arylnitromethane products are precursors for numerous useful synthetic products. An efficient method for their direct conversion to the corresponding oximes and aldehydes in a one-pot operation has been discovered. The process exploits inexpensive nitromethane as a carbonyl equivalent, providing a mild and convenient formylation method that is compatible with many functional groups.

The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon

Important defense agents against chemical warfare weapons, which are reactivators of human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus compounds (OP), need a reasonable permeation of the hematoencephalic barrier (HB). In this wo

COMPOSITIONS AND METHODS FOR MODULATING FXR

The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of Farnesiod X receptors (FXR).

Novel oxidative nitrogen to carbon rearrangement found in the conversion of anilines to benzaldoximes by treating with HCHO/H2O2

Novel rearrangement was found by reacting anilines with HCHO/H2O2 resulting in the synthesis of various benzaldoximes. The mechanism of the rearrangement is proposed and suggested that the rearrangement might proceed via unstable N-phenyloxazirane intermediate followed by the transfer of aryl moiety from nitrogen to carbon atom leading to the formation of benzaldoxime.

1-substituted, 3-carboxylic acid piperidine derivatives

The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.

Process for preparing N,O-dialkylhydroxylamine, its salts or intermediates in their synthesis

A process for preparing N,O-dialkylhydroxycarbamic acid ester which comprises reacting hydroxylamine or its salt with dihydrocarbyl carbonate in the presence of a basic compound to prepare hydroxycarbamic acid ester and subsequently alkylating this compound with an alkylating agent; a process for recovering N,O-dialkylhydroxycarbamic acid ester which comprises azeotropically distilling the ester with water from a solution containing the ester; a process for preparing N,O-dialkylhydroxylamine which comprises hydrolyzing N,O-dialkylhydroxycarbamic acid ester in an aqueous solution or a hydrous solvent in the presence of an alkali; a process for purifying N,O-dialkylhydroxylamine hydrochloride which comprises adding aldehyde or ketone to a solution of N,O-dialkylhydroxylamine hydrochloride containing O-alkylhydroxylamine hydrochloride as impurities to convert the O-alkylhydroxylamine hydrochloride into O-alkyl aldoxime or O-alkyl ketoxime and subsequently separating the N,O-dialkylhydroxylamine hydrochloride from the reaction system; and a process for separating N,O-dialkylhydroxylamine hydrochloride which comprises (i) adding benzene or alkylated benzene to an aqueous solution containing N,O-dialkylhydroxylamine hydrochloride, azeotropically removing water or a hydrochloride solution, and, subsequently (ii)adding alcohol thereto to obtain N,O-dialkylhydroxylamine hydrochloride in the form of crystal.

Reactivity of nitronate salts. Application to oxyme synthesis by reaction of nitronates on aromatics in acidic medium

Nitronates salts from nitromethane and nitroethane react in acids with aromatics to yield oximes.With benzene, the reaction gives oximes (mostly the Z isomer) of benzaldehyde and acetophenone, the best yields being observed when using anhydrous hydrogen fluoride.Reaction with activated aromatics (toluene, phenol, anisole) affords the corresponding oximes, the regioselectivity being in agreement with an electrophilic aromatic substitution.The postulated mechanism implies hydroxynitrilium ions as intermediates, on which kinetically controlled addition of aromatics, gives Z-oximes.Key words: nitronates / oximes / hydroxynitrilium ions / hydrogen fluoride