127628-06-2

Basic information

• Product Name: (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile
• CAS NO: 127628-06-2
• Molecular Weight: 355.524
• Mol File: 127628-06-2.mol

Chemical Properties

• CAS DataBase Reference: (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile(127628-06-2)
• EPA Substance Registry System: (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile(127628-06-2)

Safety Data

• Hazardous Substances Data: 127628-06-2(Hazardous Substances Data)

Upstream product

• 127628-05-1 1-[(3R,5R,8aR)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-yl]-pentylideneamine 
• 127708-18-3 (3R,5R,8aR)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 151-50-8 potassium cyanide 
• 127708-19-4 (R)-2-[(R)-2-((R)-1-Amino-pentyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-1-yl]-2-phenyl-ethanol 

Downstream Products

• 127628-07-3 (R)-2-((6R,7R)-7-Butyl-1,8-diaza-spiro[5.5]undec-1-yl)-2-phenyl-ethanol 

Relevant articles and documents

ASYMMETRIC SYNTHESIS XX. PREPARATION OF A NOVEL SPIROPIPERIDINE SYSTEM BY THE CN(R,S) METHOD.

A novel spiropiperidine system i.e. an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3.The suitable quaternary carbon was created by alkylation at the position α to the nitrile followed by transformation of the nitrile group into a primary amine.Final aminoreductive cyclisation gave the spiro system.