127708-19-4

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 127708-18-3 (3R,5R,8aR)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 

Downstream Products

• 127628-07-3 (R)-2-((6R,7R)-7-Butyl-1,8-diaza-spiro[5.5]undec-1-yl)-2-phenyl-ethanol 
• 127628-06-2 (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS XX. PREPARATION OF A NOVEL SPIROPIPERIDINE SYSTEM BY THE CN(R,S) METHOD.

A novel spiropiperidine system i.e. an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3.The suitable quaternary carbon was created by alkylation at the position α to the nitrile followed by transformation of the nitrile group into a primary amine.Final aminoreductive cyclisation gave the spiro system.