127708-18-3

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 

Downstream Products

• 96838-95-8 (3R,5R)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine 
• 96894-82-5 (R)-2-[(2R,6S)-2-(2-[1,3]Dioxolan-2-yl-ethyl)-6-propyl-piperidin-1-yl]-2-phenyl-ethanol 
• 96838-90-3 (R)-2-[(2R,6R)-2-(2-[1,3]Dioxolan-2-yl-ethyl)-6-propyl-piperidin-1-yl]-2-phenyl-ethanol 
• 135500-43-5 (6R,7R,8R)-1-Benzyl-7-butyl-1-aza-spiro[5.5]undecan-8-ol 
• 135500-42-4 (6R,7S,8S)-1-Benzyl-7-butyl-1-aza-spiro[5.5]undecan-8-ol 
• 135384-10-0 1-[(R)-2-(2-[1,3]Dioxolan-2-yl-ethyl)-1-((R)-2-hydroxy-1-phenyl-ethyl)-piperidin-2-yl]-ethanol 
• 135384-12-2 1-[(R)-1-Benzyl-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-2-yl]-ethanone 
• 135384-11-1 1-[(R)-1-Benzyl-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-2-yl]-ethanol 
• 135500-41-3 (S)-1-Benzyl-7-butyl-1-aza-spiro[5.5]undec-7-ene 
• 135384-14-4 (6R,7R)-1-Benzyl-7-butyl-1-aza-spiro[5.5]undecan-7-ol 
• 135500-40-2 (+)-1-benzyl-1-azaspiro<5.5>undecan-7-one 
• 135384-13-3 (R)-1-Benzyl-1-aza-spiro[5.5]undec-8-en-7-one 
• 127628-04-0 (R)-2-[(R)-2-((S)-1-Amino-pentyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-1-yl]-2-phenyl-ethanol 
• 127708-19-4 (R)-2-[(R)-2-((R)-1-Amino-pentyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-1-yl]-2-phenyl-ethanol 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS XX. PREPARATION OF A NOVEL SPIROPIPERIDINE SYSTEM BY THE CN(R,S) METHOD.

A novel spiropiperidine system i.e. an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3.The suitable quaternary carbon was created by alkylation at the position α to the nitrile followed by transformation of the nitrile group into a primary amine.Final aminoreductive cyclisation gave the spiro system.

Asymmetricsynthesis. XXXII. Formalsynthesisof (-) - Perhydrohistrionicotoxin

The synthesis of (-)-depentylperhydrohistrionicotoxin 2 from the 2-cyano-6-oxazolopiperidine synthon (-) 3 has been achieved. The spiro skeleton was formed by an aldol cyclization of a methyl ketone and an aldehyde function belonging to chains borne at C-

ASYMMETRIC SYNTHESIS III. ENANTIOSPECIFIC SYNTHESIS OF THE NATURAL 3R,5R,9R (-) GEPHYROTOXIN-223 AB

The first enantiospecific synthesis of the indolizidine alkaloid (-) gephyrotoxin-223 AB 2 has been achieved from the chiral 2-cyano-6-oxazolopiperidine synthon 3.