127628-07-3

Upstream product

• 127628-06-2 (6R,7R,9S)-7-Butyl-1-((R)-2-hydroxy-1-phenyl-ethyl)-1,8-diaza-spiro[5.5]undecane-9-carbonitrile 
• 127708-18-3 (3R,5R,8aR)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-carbonitrile 
• 127708-19-4 (R)-2-[(R)-2-((R)-1-Amino-pentyl)-2-(2-[1,3]dioxolan-2-yl-ethyl)-piperidin-1-yl]-2-phenyl-ethanol 
• 127628-05-1 1-[(3R,5R,8aR)-5-(2-[1,3]Dioxolan-2-yl-ethyl)-3-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-yl]-pentylideneamine 
• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 

Relevant academic research and scientific papers

ASYMMETRIC SYNTHESIS XX. PREPARATION OF A NOVEL SPIROPIPERIDINE SYSTEM BY THE CN(R,S) METHOD.

A novel spiropiperidine system i.e. an aza structural analog of histrionicotoxin has been constructed from 2-cyano-6-phenyloxazolopiperidine synthon 3.The suitable quaternary carbon was created by alkylation at the position α to the nitrile followed by transformation of the nitrile group into a primary amine.Final aminoreductive cyclisation gave the spiro system.