127751-08-0

Basic information

• Product Name: Tetrakis(2-propynyloxymethyl) methane
• Synonyms: Tetrakis(2-propynyloxymethyl) methane;3,3'-[[2,2-bis[(2-propyn-1-yloxy)methyl]-1,3-propanediyl]bis(oxy)]bis-1-Propyne;1,3-bis(prop-2-ynoxy)-2,2-bis(prop-2-ynoxymethyl)propane
• CAS NO: 127751-08-0
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288
• Mol File: 127751-08-0.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated)
• CAS DataBase Reference: Tetrakis(2-propynyloxymethyl) methane(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrakis(2-propynyloxymethyl) methane(127751-08-0)
• EPA Substance Registry System: Tetrakis(2-propynyloxymethyl) methane(127751-08-0)

Safety Data

• Hazardous Substances Data: 127751-08-0(Hazardous Substances Data)

Usage

Uses

Tetrakis(2-propynyloxymethyl)methane is used in preparation of Aminoglycoside Cyclic Oligosaccharides as Multimeric P- and E-selectin antagonists.

Upstream product

• 115-77-5 Pentaerythritol 
• 624-65-7 2-propynyl chloride 
• 106-96-7 propargyl bromide 

Downstream Products

• 1453118-16-5 C₁₀₅H₁₄₄N₂₀O₄₀ 

Relevant articles and documents

Star polymers by photoinduced copper-catalyzed azide-alkyne cycloaddition click chemistry

Well-defined star polymers consisting of tri-, tetra-, or octa-arms have been prepared via coupling-onto strategy using photoinduced copper(I)-catalyzed 1,3-dipolar cycloaddition click reaction. An azide end-functionalized polystyrene and poly(methyl meth

Sliding-graft interpenetrating polymer networks from simultaneous "Click Chemistry" and atom transfer radical polymerization

In this work, a kind of semi-interpenetrating polymer network (s-IPN) with unique molecular structures, poly(ethylene glycol) (PEG) network with movable sliding-grafted poly(2-hydroxyethyl methacrylate) (PHEMA) (sIPN-PEG/α -CD-sg- PHEMA), were first reported. sIPN-PEG/α -CD-sg-PHEMAs were prepared by simultaneous "click chemistry" and atom transfer radical polymerization (ATRP) of a mixture of poly(ethylene glycol)-diazide/ bromobutyryloxy R-cyclodextrin inclusion complex (N3-PEGN3/( R-CD-BIBB)m), tetrakis(2-propynyloxymethyl) methane (TMOP), CuBr, pentamethyldiethylenetriamine (PMDETA), HEMA and DMF. Attributable to the controlled characters of ATRP and the quantitative yields of "click chemistry", the prepared sIPN-PEG/α -CD-sg-PHEMAs have the well-defined PEG networks, as well as uniform and tunable sliding-grafted PHEMA chains. The length of sliding-grafted PHEMA of the sIPN-PEG/α -CD-sg-PHEMA can be regulated by changing polymerization times. The molecular structures, and physical and thermal properties of the sIPN-PEG/α -CD-sg-PHEMA were studied by FTIR, 1HNMR, XPS, TGA, and DSC measurements. The sIPN-PEG/α -CD-sg-PHEMAs exhibit good physical and mechanical properties. Most important, comparing to classical semi-IPN, the diffusion of interpenetrated PHEMA from sIPN-PEG/α -CD-sg-PHEMA was largely prevented for a long time solvent immersion because the PHEMA brushes were fixed on PEG networks. The sliding-grafted PHEMA chains afford functionalities to the bulk and surface of s-IPN-PEG and could potentially be used as carriers of genes and drugs.

A water-soluble AIE-active polyvalent glycocluster: Design, synthesis and studies on carbohydrate-lectin interactions for visualization of Siglec distributions in living cell membranes

In this work, we designed and synthesized an aggregation-induced emission (AIE)-active tetraphenylethene-decorated pseudo-trisialic acid (TPE3S) and validated its high affinity for Siglecs using microscale thermophoresis techniques. TPE3S was a unique binding-on fluorescent trivalent sialocluster which was successfully utilized for the visualization of Siglecs expressed on the surface of mammalian cells.

Telodendrimer-Based Macromolecular Drug Design using 1,3-Dipolar Cycloaddition for Applications in Biology

An architectural polymer containing hydrophobic isoxazole-based dendron and hydrophilic polyethylene glycol linear tail is prepared by a combination of the robust ZnCl2 catalyzed alkyne-nitrile oxide 1,3-dipolar cycloaddition and esterification chemistry. This water soluble amphiphilic telodendrimer acts as a macromolecular biologically active agent and shows concentration dependent reduction of glioblastoma (U251) cell survival.

Cluster glycosides and heteroglycoclusters presented in alternative arrangements

Multivalent carbohydrates, or glycoclusters, are useful tools to study glycan-lectin and glycan-enzyme recognition processes and have wide potential therapeutic applicability. Herein, we report the synthesis of novel glycoclusters presenting glucopyranose

Synthesis of structure-defined branched hyaluronan tetrasaccharide glycoclusters

Hyaluronan is a glycosaminoglycan with a large number of biological activity. Hyaluronan of different molecular weight often shows different biological activity, sometimes even completely opposite, but the mechanism is not clear. Herein, the hyaluronan tetrasaccharide glycoclusters using hyaluronan tetrasaccharide obtained by enzymolysis of natural hyaluronan were firstly synthesized in high yield. The structurally determined and diverse glycoclusters were of wide molecular weight range and might be used for mimicking the biological activity of natural hyaluronan and facilitating the mechanism study.

Construction of di-scFv through a trivalent alkyne-azide 1,3-dipolar cycloaddition

Heterofunctional azide and alkyne PEG-linkers have been synthesized and site specifically conjugated to scFv via a reactive thiol functionality; two scFv were coupled by copper catalyzed 1,3-dipolar cycloaddition to make divalent scFv (di-scFv) with an inter-scFv distance defined to provide divalent binding; antigen binding was maintained for the di-scFv construct and increased several times compared to that of the parent scFv; the cycloaddition reaction reported herein represents an important ligation strategy to covalently link macromolecular proteins and retain sensitive structural conformations. The Royal Society of Chemistry.

Tetrastyrene compounds containing sialic acid glycosyl units, and preparation method and application thereof

The invention relates to detection of sialidase activity by an aggregation induced luminescence probe. In particular, the invention relates to two tetrastyrene compounds containing sialic acid glycosyl units, and a preparation method and an application th

Water-soluble Glucosamine-coated AIE-Active Fluorescent Organic Nanoparticles: Design, Synthesis and Assembly for Specific Detection of Heparin Based on Carbohydrate–Carbohydrate Interactions

Two water-soluble carbohydrate-coated AIE-activate fluorescent organic nanoparticles TPE3G and TPE4G were designed and synthesized for the detection of heparin. Different from the reported strategy, we not only utilized the general detection mechanism of