127787-74-0

Upstream product

• 108-86-1 bromobenzene 
• 2051-90-3 Dichlorodiphenylmethane 
• 61623-62-9 1-(p-bromophenyl)-1,1-diphenylcarbinol 
• 71-43-2 benzene 
• 98-88-4 benzoyl chloride 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 

Downstream Products

• 68494-29-1 1-bromo-4-(triphenylmethyl)benzene 
• 82361-63-5 di-p-biphenylylphenylmethane 
• 61623-62-9 1-(p-bromophenyl)-1,1-diphenylcarbinol 
• 936630-41-0 (4-bromophenyl)diphenylmethanamine 
• 23593-77-3 1-(4-bromo-trityl)-1H-imidazole 
• 127787-71-7 dimethyl <(4-bromophenyl)diphenylmethyl>phosphonate 
• 5410-05-9 ((4-bromophenyl)methylene)dibenzene 
• 15658-11-4 p-hydroxytrityl alcohol 
• 53847-33-9 4-bromo-N-(diphenylmethylidene)aniline 
• 574-45-8 N-(diphenylmethylidene)phenylamine 
• 856204-48-3 4-chloro-trityl bromide 

Relevant academic research and scientific papers

Base-induced rearrangement of tritylamines to imines: discovery and investigation of the mechanism

An unexpected compound, the aniline derived benzophenone imine, was isolated when tritylamine was treated with n-BuLi and alkyl halides, during the formation of N-alkyl tritylamines, in the process of preparing primary amines. A nucleophilic attack of the nitrogen anion of tritylamide on the adjacent C-bonded phenyl, either substituted or not, involving a bridging anionic intermediate, is proposed for this base-induced tritylamine rearrangement to produce the corresponding imine. Electron-withdrawing groups in the aromatic ring, favoring the negative charge development, affect the relative migratory tendencies.

Synthesis and antifungal activity of a series of difluorotritylimidazoles

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and trifluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole.