15658-11-4Relevant academic research and scientific papers
Flash photolytic generation and study of p-quinone α-phenylmethide and p-quinone α,α-diphenylmethide in aqueous solution
Chang,Kresge,Zhan,Zhu
, p. 579 - 585 (2004)
p-Quinone α-phenylmethide (7) and p-quinone α,α- diphenylmethide (8) were generated by flash photolytic dehydration of p-hydroxy-α-phenylbenzyl alcohol (9, R1 =Ph, R2 = H) and p-hydroxy-α,α-diphenylbenzyl alcohol (9, R1 = R 2 = Ph) respectively, and rates of their decay were measured in aqueous perchloric acid and sodium hydroxide solutions and also as in acetic acid, biphosphate ion, tris(hydroxymethyl)methylammonium ion, ammonium ion and bicarbonate ion buffers. The rate profiles for the hydration of these quinone methides that these data provide show hydronium ion and hydroxide ion-catalyzed regions and also 'uncatalyzed' water reactions, with saturation of hydronium ion catalysis in dilute solution for the diphenyl-substituted substrate but only in concentrated acid solution for the less basic monophenyl substrate. Both substrates also give inverse hydronium ion isotope effects (k H+/kD+ 1). These results show that the hydronium ion-catalyzed reactions occur by rapid pre-equilibrium protonation of the quinone methide on its carbonyl oxygen atom followed by rate-determining capture of the benzyl-type carbocation thus formed by water. Phenyl substitution retards the rate of hydration and also reduces the acidity constant of the quinone methide conjugate acid. The molecular basis of these substituent effects is discussed. Copyright
Compound containing diphenylmethane structure
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Paragraph 0227; 0228; 0229; 0230, (2019/05/08)
The invention relates to a compound containing a diphenylmethane structure, and belongs to the technical field of compounds and polypeptide synthesis. The structure of the compound containing the diphenylmethane structure is shown in general formula (1).
A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors
Bang, Claus G.,Jensen, Jakob F.,O'Hanlon Cohrt, Emil,Olsen, Lasse B.,Siyum, Saba G.,Mortensen, Kim T.,Skovgaard, Tine,Berthelsen, Jens,Yang, Liang,Givskov, Michael,Qvortrup, Katrine,Nielsen, Thomas E.
supporting information, p. 657 - 669 (2017/10/13)
We herein present broadly useful, readily available and nonintegral hydroxylamine linkers for the routine solid-phase synthesis of hydroxamic acids. The developed protocols enable the efficient synthesis and release of a wide range of hydroxamic acids from various resins, relying on high control and flexibility with respect to reagents and synthetic processes. A trityl-based hydroxylamine linker was used to synthesize a library of peptide hydroxamic acids. The inhibitory effects of the compounds were examined for seven HDAC enzyme subtypes using a chemiluminescence-based assay.
The Reduction of Fluorine-containing Triarylmethanols by Formic Acid
Andrews, Adrian F.,Mackie, Raymond K.,Walton, John C.
, p. 96 - 102 (2007/10/02)
Triarylmethanols containing one or more fluorine substituents in the para-positions are converted by 90 percent formic acid into a mixture of the fluorine-containing triarylmethane, and a second component in which one fluorine has been replaced by a hydro
