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2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is a stable organic compound derived from tetrahydrofuran, a colorless liquid commonly used as a solvent. It is characterized by its potential therapeutic effects and versatility in organic synthesis, making it a valuable precursor in the synthesis of other organic compounds.

127915-15-5

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127915-15-5 Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is used as a precursor in pharmaceutical research and drug development for its potential therapeutic effects. It can be modified to create new drugs, contributing to the discovery and development of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-oxotetrahydrofuran-3-carboxylic acid methyl ester is used as a building block for the synthesis of various organic compounds. Its versatility allows for the creation of a wide range of chemical products.
Used in Specialty Chemicals Production:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is utilized in the production of specialty chemicals, where its unique properties contribute to the development of high-value chemical products.
Used in Flavor and Fragrance Industry:
2-oxotetrahydrofuran-3-carboxylic acid methyl ester also finds applications in the flavor and fragrance industry, where it is used to create unique scents and tastes for various consumer products.
Used in Other Industrial Products:
2-Oxotetrahydrofuran-3-carboxylic acid methyl ester is employed in various other industrial applications, showcasing its diverse uses and the importance of this chemical compound in multiple sectors.

Check Digit Verification of cas no

The CAS Registry Mumber 127915-15-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,9,1 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 127915-15:
(8*1)+(7*2)+(6*7)+(5*9)+(4*1)+(3*5)+(2*1)+(1*5)=135
135 % 10 = 5
So 127915-15-5 is a valid CAS Registry Number.

127915-15-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-oxo-tetrahydro-furan-3-carboxylic acid methyl ester

1.2 Other means of identification

Product number -
Other names 2-oxo-tetrahydrofuran-3-carboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127915-15-5 SDS

127915-15-5Relevant articles and documents

-Alkoxystannyl ethers in organic synthesis: Synthesis of functionalised γ-butyrolactones

Gilbert, Philip,Lewis, Mark L.,Quayle, Peter,Zhao, Yuekun,Mills, Keith

, p. 9115 - 9118 (1996)

Ozonolysis of a variety of (tetraydrofuran-2-yl)tri-n-butylstannanes affords the corresponding γ-butyrolactones in good to excellent yields. This reaction is tolerant to a range of other functional groups and provides access to substituted γ-butyrolactone

Hydroxyalkylation and Lactone Formation from Dialkyl Malonate by Means of a EuIII/EuII Photoredox System

Ishida, Akito,Yamashita, Shinya,Takamuku, Setsuo

, p. 2229 - 2231 (1988)

A EuIII/EuII photoredox system in alcohol induced an effective hydroxyalkylation at an α-position of a dialkyl malonate.The alcohol adduct was then converted to the lactone.A step-by-step hydroxyalkylation mechanism was suggested in which the Eu ion is used as a photocatalyst and also as a condensation catalyst for the reaction of dialkyl malonates and aldehydes.

Enantioselective phase-transfer catalytic α-benzylation and α-allylation of α-tert-butoxycarbonyllactones

Ha, Min Woo,Lee, Heejin,Yi, Hye Yeong,Park, Yohan,Kim, Sori,Hong, Suckchang,Lee, Myungmo,Kim, Mi-Hyun,Kim, Taek-Soo,Park, Hyeung-Geun

, p. 637 - 642 (2013)

A new enantioselective α-benzylation and α-allylation of α-tert-butoxycarbonyllactones was devloped. α-Benzylation and α-allylation of α-tert-butoxycarbonylbutyrolactone and α-tert-butoxycarbonylvalerolactone under phase-transfer catalytic conditions (50% cesium hydroxide, toluene, -60 °C) in the presence of (S,S)-3,4,5-trifluorophenyl-NAS bromide (1 mol%) afforded the corresponding α-substituted α-tert-butoxycarbonyllactones in very high chemical yields (up to 99%) and optical yields (up to 99% ee). The synthetic potential of this method has been successfully demonstrated by the asymmetric synthesis of unnatural α-quaternary homoserines, 3-alkyl-3-carboxypyrrolidine and 3-alkyl-3-carboxypiperidine. Copyright

BICYCLIC HETEROARENES AND METHODS OF THEIR USE

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Page/Page column 67-68, (2021/12/30)

Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Duchemin, Nicolas,Buccafusca, Roberto,Daumas, Marc,Ferey, Vincent,Arseniyadis, Stellios

supporting information, p. 8205 - 8210 (2019/10/16)

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy)carbamates

Hazelden, Ian R.,Carmona, Rafaela C.,Langer, Thomas,Pringle, Paul G.,Bower, John F.

supporting information, p. 5124 - 5128 (2018/03/26)

Ligand-enabled aza-Heck cyclizations and cascades of N-(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non-biased 6-exo aza-Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation

Kawada, Hatsuo,Ebiike, Hirosato,Tsukazaki, Masao,Nakamura, Mitsuaki,Morikami, Kenji,Yoshinari, Kiyoshi,Yoshida, Miyuki,Ogawa, Kotaro,Shimma, Nobuo,Tsukuda, Takuo,Ohwada, Jun

supporting information, p. 673 - 678 (2013/02/23)

Our lead compound for a phosphoinositide 3-kinase (PI3K) inhibitor (1) was metabolically unstable because of rapid glucuronidation of the phenol moiety. Based on structure-activity relationship (SAR) information and a FlexSIS docking simulation score, aminopyrimidine was identified as a bioisostere of phenol. An X-ray structure study revealed a hydrogen bonding pattern of aminopyrimidine derivatives. Finally, aminopyrimidine derivatives 33 showed strong tumor growth inhibition against a KPL-4 breast cancer xenograft model in vivo.

HETEROCYCLIC AMIDES AS ROCK INHIBITORS

-

Page/Page column 80, (2011/10/03)

The present invention relates to new kinase inhibitors of formula (I), more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

PYRIMIDINE DERIVATIVE AS PI3K INHIBITOR AND USE THEREOF

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Page/Page column 147, (2009/05/29)

A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility. A compound, or pharmaceutically acceptable salt thereof, rep

SYNTHESIS OF TETRAHYDRO-1,2-OXAZINES BY THE CYCLOADDITION OF NITRONES WITH CYCLOPROPANES

-

Page 4; 18, (2010/02/08)

One aspect of the present invention relates to a method of preparing tetrahydro-1,2- oxazines comprising the step of combining a nitrone and a cyclopropane in the presence of a Lewis acid. Another aspect of the present invention relates to a method of preparing a tetrahydro-1,2-oxazine, comprising the step of combining an aldehyde and a hydroxylamine in the presence of a Lewis acid to generate a nitrone in situ, then admixing a cyclopropane. Another aspect of the present invention relates to converting a tetrahydro-l,2-oxazine to a pyrrolidine comprising the step of admixing a tetrahydro-1,2-oxazine and a reducing agent.

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