128272-26-4

Basic information

• Product Name: METHYL 2-FLUORO-4-METHOXYBENZOATE
• Synonyms: METHYL 2-FLUORO-4-METHOXYBENZOATE;RARECHEM AL BF 0456
• CAS NO: 128272-26-4
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.16
• Product Categories: Acids & Esters;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 128272-26-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 250.1 °C at 760 mmHg
• Flash Point: 102.1 °C
• Appearance: /
• Density: 1.184 g/cm³
• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: METHYL 2-FLUORO-4-METHOXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-FLUORO-4-METHOXYBENZOATE(128272-26-4)
• EPA Substance Registry System: METHYL 2-FLUORO-4-METHOXYBENZOATE(128272-26-4)

Safety Data

• Hazardous Substances Data: 128272-26-4(Hazardous Substances Data)

Usage

General Description

Methyl 2-fluoro-4-methoxybenzoate is a chemical compound with the molecular formula C9H9FO3. It is a member of the benzoate ester family and is commonly used in the pharmaceutical and agrochemical industries as an intermediate in the synthesis of various organic compounds. METHYL 2-FLUORO-4-METHOXYBENZOATE is known for its fluoro and methoxy functional groups, which make it useful for drug development and crop protection. It is a white to off-white crystalline powder with a melting point of 75-78°C and a boiling point of 258-260°C. Methyl 2-fluoro-4-methoxybenzoate is also used as a building block in organic synthesis and can be found in various research and industrial applications.

InChI:InChI=1/C9H9FO3/c1-12-6-3-4-7(8(10)5-6)9(11)13-2/h3-5H,1-2H3

Upstream product

• 865-33-8 potassium methanolate 
• 106614-28-2 methyl 2,4-difluorobenzoate 
• 124-41-4 sodium methylate 
• 865-34-9 lithium methanolate 
• 67-56-1 methanol 
• 394-42-3 2-fluoro-4-methoxy-benzoic acid 

Downstream Products

• 949465-86-5 5-methyl 5-bromo-2-fluoro-4-methoxybenzoate 
• 1290181-50-8 tert-butyl 4-(4-(3-(tert-butoxycarbonylamino)-5-cyano-6-(2-fluoro-4-methoxyphenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-yl)phenyl)piperazine-1-carboxylate 
• 1290181-04-2 3-(2-fluoro-4-methoxyphenyl)-3-oxopropanenitrile 
• 405-09-4 (2-fluoro-4-methoxyphenyl)methanol 

Relevant articles and documents

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND

The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Spe